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This book discusses the various challenges as well as concerns regarding sepsis. Sepsis has led to innumerous deaths in non-cardiologic intensive care units across the globe and researches are being conducted to comprehend the complexity of pathophysiology for obtaining future therapeutic opportunities. Billions of dollars are being consumed every year for the treatment of sepsis and research. Even then, the mortality rates continue to increase. This book covers various aspects of sepsis. It provides an overview of the history of sepsis and treatment of sepsis-related organ dysfunctions. It also discusses about pathophysiological and therapeutic characteristics of sepsis and includes research works of renowned experts and practitioners in this field. The book aims to increase the awareness of healthcare teams about important aspects of this severe condition such as early recognition and treatment of this disease.