The growth and reproduction of herbivores is constrained by both plant quality and predation by higher trophic levels. Certain herbivores have found a way out of this quandary by redirecting plant defenses against their own predators: By ingesting and accumulating plant toxins, a phenomenon referred to as sequestration, herbivores may make themselves unattractive or toxic to natural enemies.The resulting transfer of plant toxins across three trophic levels is increasingly recognized as a powerful force that shapes the distribution and abundance of plants, herbivores and predators in natural and agricultural ecosystems.