This study was carried out to investigate the seroprevalence and risk factors of PPR in sheep in Kassala and North Kordofan states, the Sudan. The overall seroprevalence was found to be 70.2%. The seroprevalences in the two states and age groups were statistically not different, however, there were differences between localities, breeds, and sex. Significant risk factors associated with a cELISA positive status for PPR in the univariate and the multivariate analyses were state, locality, breed, sex and number of males. Questionnaire survey showed that sheep owners and herders have a solid good knowledge of PPR infection. At the same time there exist considerable reservations of a sizeable number of herders against vaccination against PPR. Investigation results suggest that PPR has taken an endemic pattern of occurrence in the Sudan as reported from other countries in East Africa. Urgent need therefore exists to initiate a realistic network for surveillance, control and eradication of this important disease in the Sudan and in the region. Such scheme is suggested and supported at high levels and it should immediately be launched as recommended by the OIE.