Severe burn is defined by skin loss greater than 25% of total body surface area, specific locations or associated lesions. It affects all age groups, but children and young adults are most at risk. Local destruction causes the release of inflammation mediators that trigger SIRS. The local disease becomes a general disease. Management involves an assessment of the burned area, Lund and Browder's table is the most accurate. Depth makes the prognosis of the disease. Vascular filling is estimated by formulas, it is delivered in flow rather than bolus to avoid leakage into the interstitial area. The approach routes must be of good calibre. In an emergency, the peripheral routes are the easiest, giving priority to healthy areas. The airway should be controlled, especially when there is a deep facial burn; intubation should not be delayed. Analgesia should be multimodal, including Tier I and Tier III medications. Small doses of ketamine provide good surface analgesia.
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