Houston Mackenzie, a shark expert in Monterey, comes upon an old article from 1938 about a shark captured off the Santa Cruz coast. That article, and a death bed confession by his grandmother, pulls him into a mystery full of murder, betrayal and guilt. Leaping between 2006 and the hard boiled times of the 1930's, Sharks and Killers follows 'Mack' and his sister Janie as they try and solve a Depression era murder that destroyed their family for decades with three simple words: "Find Dan McCullough".