H.J. Binder / J. Cummings / K. Soergel (Hgg.)

Short Chain Fatty Acids

Herausgegeben:Binder, H. J.; Cummings, J.; Soergel, K.

• Gebundenes Buch

Produktbeschreibung

Short chain fatty acids (SFCA) are synthesized by the colonic microflora primarily from non-absorbed carbohydrate; there is also some limited production from non-absorbed protein. In contrast, SFCA are not normally present in the diet. During the past 15 years SFCA have attracted considerable interest in human nutrition, physiology and pathophysiology as a result of the realization that SFCA represent an important mechanism for carbohydrate and calorie conservation and may play a role in various types of colitides and possibly in colonic neoplasia. In addition, SFCA, produced in large amounts by ruminants and other herbivores, have long been the province of veterinary physiologists.
This book is based upon the presentations at the 73rd Falk Symposium held in Strasbourg, France, September 8--10, 1993, which brought together researchers and clinicians from five continents. It provides an excellent statement of the present state-of-the-art knowledge of SFCA.

Produktdetails

• Falk Symposium 73
• Verlag: Springer / Springer Netherlands
• Artikelnr. des Verlages: 978-0-7923-8849-4
• 1994.
• Seitenzahl: 306
• Erscheinungstermin: 31. März 1994
• Englisch
• Abmessung: 241mm x 160mm x 22mm
• Gewicht: 612g
• ISBN-13: 9780792388494
• ISBN-10: 0792388496
• Artikelnr.: 21345770

Inhaltsangabe

Introduction. Section I: Short Chain Fatty Acid Production. 1. Control of
short chain volatile acid production in the colon; M.J. Wolin. 2.
Quantitating short chain fatty acid production in humans; J.H. Cummings.
3. Energy value of fermentation; E. Wisker, W. Feldheim. 4. Segmental
differences in colonic function; G.I. Sandle. 5. Short chain fatty acid and
lactate production by human intestinal bacteria grown in batch and
continuous culture; G.T. Macfarlane, G.R. Gibson, S. Macfarlane. 6. In vivo
models for short chain fatty acid production; T. Midtvedt. Section II:
Short Chain Fatty Acid Absorption. 7. Methodological approaches to study
colonic short chain fatty acid transport; J.H. Sellin. 8. In vitro studies
of short chain fatty acid transport with intact tissue; G. Rechkemmer. 9.
Short chain fatty acid transport by human intestinal apical membranes; K.
Ramaswamy, J.M. Harig, K.H. Soergel. 10. Short chain fatty acid stimulation
of electroneutral Na--Cl absorption: role of apical SCFA--HCO3 and SCFA--Cl
Exchanges; V.M. Rajendran, H.J. Binder. Section III: Colonocyte Biology.
11. Colonocyte differentiation and proliferation: overview and the
butyrate-induced transcriptional regulation of oncodevelopmental
placental-like alkaline phosphatase gene in colon cancer cells; Y.S. Kim,
J.R. Gum, S.B. Ho, G. Deng. 12. Effect of butyrate on gene expression; J.
Kruh, L. Tichonicky, N. Defer. 13. Butyrate and the colorectal cancer cell;
G.P. Young, P.R. Gibson. 14. Short chain fatty acids and postoperative
intestinal adaptation; K.J. Reilly, W.L. Frankel, J.L. Rombeau. 15.
Cellular metabolism of colonocytes; J.R. del Castillo, R. Muñiz, M.C.
Súlbaran-Carrasco, S. Pekerar. Section IV: Short Chain Fatty Acids and
Colonic Diseases. 16. The imprint of disease on short chain fatty acid
metabolism by colonocytes; W.E.W. Roediger. 17. Short chain fatty acids
improve epithelia in ulcerative colitis? Speculation on mechanisms; W.
Scheppach. 18. Short chain fatty acid rectal irrigation therapy for
left-sided ulcerative colitis: A randomized, placebo-controlled clinical
trial. Interim report; R.I. Breuer, M.L. Christ, B.A. Lashner, K.H.
Soergel, S.B. Hanauer, J.M. Harig, ZM. Robinson, A. VAnagunas, A.
Keshavarzian, T. Wardzala, M. Hinkle, M. Desai, A. Rademaker. 19. The use
of short chain fatty acids in oral rehydration solutions; B.S. Ramakrishna.
20. Mechanism of carbohydrate-induced diarrhoea; J.-C. Rambaud, B.
Flourié. 21. Antibiotic-associated diarrhoea; P.B. Mortensen, M.R. Clausen.
Section V: Short Chain Fatty Acids and Metabolism. 22. Short chain fatty
acids and carbohydrate metabolism; T. Wolever. 23. Propionate -- sources
and effect on lipid metabolism; A. Stephen. 24. Short chain fatty acids and
hepatic metabolism; C. Demigné, C. Ré mésy. Index.