Side Reactions in Peptide Synthesis, based on the author's academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly…mehr
Side Reactions in Peptide Synthesis, based on the author's academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.
This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development.
While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay.
Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.
Yi Yang began researching peptide synthesis in 2003, and obtained his doctoral degree at Bielefeld University, Germany in 2008. Dr. Yang worked for three years at Lonza AG, Visp, Switzerland as R&D and Process Peptide Chemist, participated in multi cGMP peptidyl API production at Lonza, which is regarded as one of the largest peptide contract manufacturing organization (CMO) in the world, serving pharmaceutical companies. He is currently the Senior Research Scientist of Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark. Dr. Yang's experience with a wide variety of peptide side reactions, from both practical and theoretical aspects, is ideal for this publication.
Inhaltsangabe
Peptide Fragmentation/Deletion
Premature FMOC Deprotection
Elimination Side Reactions
Peptide Global Deprotection/Scavenger-Induced Side Reactions
Peptide Rearrangement Side Reactions
Side Reactions Occurring at Amino Acid/Peptide Activation Step
Intramolecular Cyclization Side Reactions
Side Reactions in Amino Groups in Peptide Synthesis
Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis
Oxidation and Reduction Side Reactions in Peptide Synthesis
Racemization in Peptide Synthesis
Solvent and Residual Impurities in the Reagents Induced Side Reactions
Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation)
