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High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! The Silver Spring monkeys were seventeen macaque monkeys living inside the Institute of Behavioral Research in Silver Spring, Maryland, who became what one writer called "the most famous lab animals in history". They came to public attention as a result of a bitter ten-year battle between scientists, animal advocates, politicians, and the courts over whether to use the animals in research or release them to a sanctuary. Within the scientific community, the monkeys are known for their role in research that led to the discovery of neuroplasticity, the ability of the brain to remap itself, regarded as one of the most exciting discoveries of the 20th century.