Recognizing the vital role that the teacher plays in the holistic development and acquisition of the 21st century skills of the learners, these session plans on Central Dogma of Molecular Biology were developed. These present teaching instructions that are integrated with computer simulations. Moreover, these session plans provide comprehensive instructions with ready-made activities, containing a detailed learning sequence of science concepts, teacher tips, and strategies in addressing diverse learner needs. Moreover, it engages learners in a number of hands-on interactive activities that make use of mixed-media to maximize existing resources. Hence, encouraging a two-way interaction between the teachers and learners that will ultimately result to effective learning. The session plans also define the content standards expected in every lesson. It also provides the answer key to the questions in the different activities and worksheet. The author hopes that this instructional material may be of great help to all the teachers who are teaching the topic Central Dogma of Molecular Biology.