It is evident from the study that the developed method is simple, specific, precise and accurate. The newly developed method can be used for routine analysis as method for the simultaneous estimation of Ethamsylate and Tranexamic acid in tablet dosage forms. In the present work, U.V. spectrophotometric method and RP-HPLC method for simultaneous estimation of Ethamsylate and Tranexamic Acid in tablet has been developed. The proposed methods are precise, accurate and do not suffer from any interference due to common excipients and/or degraded impurities The validation parameters according to I.C.H Q2B guidelines were studied. The accuracy of the methods was proved by performing recovery studies in available formulations. Values greater than 98% indicate that the proposed method is accurate for the analysis of drug.