Successful endodontic treatment depends upon localization, proper chemo-mechanical preparation of the root canal system, debridement, shaping, disinfection, and three dimensional obturation of canal system. Thus multiple sitting endodontic therapy was advocated and followed. Single visit endodontic treatment had various drawbacks mainly concerning with post-operative pain and failure of the treatment outcome. With the advent of newer technology, elimination of these various drawbacks of single visit endodontic therapy could be made possible in many scenarios. The present article discussed the various case selection, indications, contraindications, patient and practice advantages with respect to single visit endodontic therapy. Present article also discusses about the adjunct used for the faster and better treatment outcomes of single visit endodontics mainly pain control, isolation access cavity preparation, light and magnification, use of irrigants and use of Laser.