We are often reluctant to abandon predictable treatment procedures because we fear a change to some new treatment modality may not result in the successful outcome.The contemporary question, "Is single-visit root canal treatment a biologically compromised treatment?" has not been conclusively answered, although numerous studies have addressed various aspects of this question. There is no short cut to success; single visit endodontics does not mean skipping of any step, rather all the steps must be systematically performed in one visit to achieve a successful outcome.Single visit versus multiple visit endodontics in light of existing concerns has hence been undertaken for comparision. The author emphasis on careful case selection and adherence to standard endodontic pinciples.