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Content: Introduction to Sirtuins The Biology of Aging The Role of Sirtuins in Aging Sirtuins and Gene Regulation Sirtuins and Cellular Metabolism Sirtuins and DNA Repair Sirtuins and Mitochondrial Function Sirtuins and Inflammation Sirtuins and Oxidative Stress Sirtuins and Longevity Pathways Sirtuins in Model Organisms Nutritional Modulation of Sirtuins Pharmacological Modulation of Sirtuins Sirtuins and Age-Related Diseases Emerging Technologies and Techniques