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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Sjögren''s syndrome (also known as "Mikulicz disease" and "Sicca syndrome") is an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva. It is named after Swedish ophthalmologist Henrik Sjögren (1899-1986) who first described it. Nine out of ten Sjögren''s patients are women and the average age of onset is late 40s, although Sjögren''s occurs in all age groups in both women and men. It is estimated to strike as many as 4 million people in the United States alone making it the second most common autoimmune rheumatic disease. Sjögren''s syndrome can exist as a disorder in its own right (Primary Sjögren''s syndrome) or it may develop years after the onset of an associated rheumatic disorder such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma, primary biliary cirrhosis etc. (Secondary Sjögren''s syndrome). An autoantigen is alpha-Fodrin.