P. Elsner / A.O. Barel / E. Berardesca / B. Gabard / J. Serup (eds.)
Skin Bioengineering
Techniques and Applications in Dermatology and Cosmetology
Mitwirkender: Elsner, Peter; Berardesca, Enzo; Barel, A. O.
P. Elsner / A.O. Barel / E. Berardesca / B. Gabard / J. Serup (eds.)
Skin Bioengineering
Techniques and Applications in Dermatology and Cosmetology
Mitwirkender: Elsner, Peter; Berardesca, Enzo; Barel, A. O.
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Non-invasive bioengineering techniques have become indispensable tools both in the development of drugs and cosmetics and in clinical dermatology. These techniques enable researchers to study the structure and function of human skin objectively and quantitatively. Recent technological developments have brought new techniques into the laboratory and the hospital, among them magnetic resonance imaging, optical coherence tomography and microdialysis. This book describes these state-of-the-art developments, details the application of skin bioengineering techniques for clinical purposes, shows…mehr
Non-invasive bioengineering techniques have become indispensable tools both in the development of drugs and cosmetics and in clinical dermatology. These techniques enable researchers to study the structure and function of human skin objectively and quantitatively. Recent technological developments have brought new techniques into the laboratory and the hospital, among them magnetic resonance imaging, optical coherence tomography and microdialysis. This book describes these state-of-the-art developments, details the application of skin bioengineering techniques for clinical purposes, shows their use in the testing of pharmaceutics and cosmetics and provides an overview of the design and legal aspects of skin bioengineering testing. It will be essential reading for dermatologists, cosmetologists, pharmacologists and toxicologists.
Produktdetails
- Produktdetails
- Current Problems in Dermatology
- Verlag: Karger
- Seitenzahl: 252
- Englisch
- Abmessung: 250mm
- Gewicht: 670g
- ISBN-13: 9783805565196
- ISBN-10: 3805565194
- Artikelnr.: 26719872
- Current Problems in Dermatology
- Verlag: Karger
- Seitenzahl: 252
- Englisch
- Abmessung: 250mm
- Gewicht: 670g
- ISBN-13: 9783805565196
- ISBN-10: 3805565194
- Artikelnr.: 26719872
1;Contents;6
2;Preface;9
3;Skin Imaging: State of the Art at the Dawn of the Year 2000;11
3.1;Semi-Invasive and Invasive Methods;11
3.2;Indirect Methods;13
3.3;Non-InvasiveMethods;15
3.4;Present and Prospective Views on Skin Imaging;19
3.5;References;19
4;In vivo Proton Magnetic Resonance Spectroscopy in Human Skin;22
4.1;Materials and Methods;23
4.2;Results;25
4.3;Discussion;28
4.4;Conclusion;28
4.5;References;29
5;Raman Spectroscopy and Skin;30
5.1;Raman Scattering;30
5.2;Instrumentation;32
5.3;Raman Spectra of Skin;33
5.4;FT Raman Spectra;33
5.5;Visible Light Raman Spectra;35
5.6;In vivo Raman Spectra;35
5.7;Conclusions;35
5.8;References;36
6;Optical Coherence Tomography of the Skin1;37
6.1;Method;38
6.2;Results;39
6.3;Discussion;44
6.4;References;47
7;Examination of Stratum corneum Hydration State by Electrical Methods;48
7.1;An Adequate Description and a Reliable Basis;51
7.2;Assessment of Stratum Corneum Hydration;51
7.3;Validity of Estimating Skin Hydration Using Single-Frequency Admittance or Susceptance Measurements;52
7.4;Understanding and Using the Biophysical Basis;55
7.5;References;56
8;Optothermal Measurement of Water Distribution within the Stratum corneum;58
8.1;Apparatus;58
8.2;Theory;60
8.3;Results;63
8.4;Conclusion;69
8.5;References;70
9;An Improved Method for the Measurement of Scalp Sebum;71
9.1;Materials and Methods;72
9.2;Results;74
9.3;Discussion;77
9.4;Conclusion;78
9.5;References;78
10;Mechanical Function of the Skin: State of the Art;79
10.1;General Description of the Instrument;81
10.2;Description of the Recorded Viscoelastic Parameters;81
10.3;Material and Methods;85
10.4;Description of the Elastic and Viscoelastic Properties of the;86
10.5;Human Skin;86
10.6;Conclusions;92
10.7;References;93
11;Thermal Sensory Analyzer;94
11.1;Boon to the Study of C and A Delta Fibers;94
11.2;Methods of Thermal Sensory Testing;95
11.3;Usefulness of Thermal Sensory Testing;96
11.4;The Future of Thermal Testing;98
11.5;References;99
12;Cutaneous Microdialysis;100
12.1;A New Technique for the Assessment of Skin Penetration;100
12.2;Cutaneous Microdialysis;100
12.3;Trauma after the Insertion of aMicrodialysis Probe into the Skin;103
12.4;In vivo Microdialysis Studies;104
12.5;Applications of Cutaneous Microdialysis;106
12.6;References;107
13;A New Method for Assessing, in vivo in Human Subjects, the Basal or UV- Induced Peroxidation of the Stratum corneum;109
13.1;Application to Test the Efficacy of Free-Radical-Scavenging Products;109
13.2;Material and Methods;110
13.3;Results;112
13.4;Discussion;115
13.5;References;116
14;Biophysical Methods for Disease Monitoring in Dermatology;118
14.1;Psoriasis;119
14.2;Localized Scleroderma;121
14.3;Systemic Sclerosis;122
14.4;Atopic Dermatitis;123
14.5;References;127
15;Skin Bioengineering in Phlebology and Angiology;130
15.1;Capillaroscopy and Fluorescence Video Microscopy;130
15.2;Quantitative Photoplethysmography;133
15.3;VibrationWorkplace Simulator;134
15.4;Local Cold Exposure Tests;136
15.5;Capillary PressureMeasurements;140
15.6;References;142
16;Skin Bioengineering Methods in the Monitoring of Scleroderma;144
16.1;Volunteers, Patients and Methods;145
16.2;Results;148
16.3;Discussion;151
16.4;References;153
17;Skin Bioengineering Methods in Occupational Dermatology;155
17.1;Skin Irritancy Tests;155
17.2;Reproducibility;158
17.3;Correlations between Different Tests;158
17.4;Prevention;158
17.5;Important In.uencing Factors;159
17.6;References;160
18;Climatic Influence on Cosmetic Skin Parameters;161
18.1;Introduction;161
18.2;Material and Methods;161
18.3;Results and Discussion;168
18.4;Conclusion;173
18.5;References;174
19;Lipid Content and Electrical Impedance;175
19.1;Lipid Structure;176
19.2;Electrical Impedance;177
19.3;Test Procedure;179
19.4;Results and Discussion;182
19.5;Conclusion;184
19.6;References;184
20;Evaluation of the Short- Term Effects of Skin C
2;Preface;9
3;Skin Imaging: State of the Art at the Dawn of the Year 2000;11
3.1;Semi-Invasive and Invasive Methods;11
3.2;Indirect Methods;13
3.3;Non-InvasiveMethods;15
3.4;Present and Prospective Views on Skin Imaging;19
3.5;References;19
4;In vivo Proton Magnetic Resonance Spectroscopy in Human Skin;22
4.1;Materials and Methods;23
4.2;Results;25
4.3;Discussion;28
4.4;Conclusion;28
4.5;References;29
5;Raman Spectroscopy and Skin;30
5.1;Raman Scattering;30
5.2;Instrumentation;32
5.3;Raman Spectra of Skin;33
5.4;FT Raman Spectra;33
5.5;Visible Light Raman Spectra;35
5.6;In vivo Raman Spectra;35
5.7;Conclusions;35
5.8;References;36
6;Optical Coherence Tomography of the Skin1;37
6.1;Method;38
6.2;Results;39
6.3;Discussion;44
6.4;References;47
7;Examination of Stratum corneum Hydration State by Electrical Methods;48
7.1;An Adequate Description and a Reliable Basis;51
7.2;Assessment of Stratum Corneum Hydration;51
7.3;Validity of Estimating Skin Hydration Using Single-Frequency Admittance or Susceptance Measurements;52
7.4;Understanding and Using the Biophysical Basis;55
7.5;References;56
8;Optothermal Measurement of Water Distribution within the Stratum corneum;58
8.1;Apparatus;58
8.2;Theory;60
8.3;Results;63
8.4;Conclusion;69
8.5;References;70
9;An Improved Method for the Measurement of Scalp Sebum;71
9.1;Materials and Methods;72
9.2;Results;74
9.3;Discussion;77
9.4;Conclusion;78
9.5;References;78
10;Mechanical Function of the Skin: State of the Art;79
10.1;General Description of the Instrument;81
10.2;Description of the Recorded Viscoelastic Parameters;81
10.3;Material and Methods;85
10.4;Description of the Elastic and Viscoelastic Properties of the;86
10.5;Human Skin;86
10.6;Conclusions;92
10.7;References;93
11;Thermal Sensory Analyzer;94
11.1;Boon to the Study of C and A Delta Fibers;94
11.2;Methods of Thermal Sensory Testing;95
11.3;Usefulness of Thermal Sensory Testing;96
11.4;The Future of Thermal Testing;98
11.5;References;99
12;Cutaneous Microdialysis;100
12.1;A New Technique for the Assessment of Skin Penetration;100
12.2;Cutaneous Microdialysis;100
12.3;Trauma after the Insertion of aMicrodialysis Probe into the Skin;103
12.4;In vivo Microdialysis Studies;104
12.5;Applications of Cutaneous Microdialysis;106
12.6;References;107
13;A New Method for Assessing, in vivo in Human Subjects, the Basal or UV- Induced Peroxidation of the Stratum corneum;109
13.1;Application to Test the Efficacy of Free-Radical-Scavenging Products;109
13.2;Material and Methods;110
13.3;Results;112
13.4;Discussion;115
13.5;References;116
14;Biophysical Methods for Disease Monitoring in Dermatology;118
14.1;Psoriasis;119
14.2;Localized Scleroderma;121
14.3;Systemic Sclerosis;122
14.4;Atopic Dermatitis;123
14.5;References;127
15;Skin Bioengineering in Phlebology and Angiology;130
15.1;Capillaroscopy and Fluorescence Video Microscopy;130
15.2;Quantitative Photoplethysmography;133
15.3;VibrationWorkplace Simulator;134
15.4;Local Cold Exposure Tests;136
15.5;Capillary PressureMeasurements;140
15.6;References;142
16;Skin Bioengineering Methods in the Monitoring of Scleroderma;144
16.1;Volunteers, Patients and Methods;145
16.2;Results;148
16.3;Discussion;151
16.4;References;153
17;Skin Bioengineering Methods in Occupational Dermatology;155
17.1;Skin Irritancy Tests;155
17.2;Reproducibility;158
17.3;Correlations between Different Tests;158
17.4;Prevention;158
17.5;Important In.uencing Factors;159
17.6;References;160
18;Climatic Influence on Cosmetic Skin Parameters;161
18.1;Introduction;161
18.2;Material and Methods;161
18.3;Results and Discussion;168
18.4;Conclusion;173
18.5;References;174
19;Lipid Content and Electrical Impedance;175
19.1;Lipid Structure;176
19.2;Electrical Impedance;177
19.3;Test Procedure;179
19.4;Results and Discussion;182
19.5;Conclusion;184
19.6;References;184
20;Evaluation of the Short- Term Effects of Skin C
1;Contents;6
2;Preface;9
3;Skin Imaging: State of the Art at the Dawn of the Year 2000;11
3.1;Semi-Invasive and Invasive Methods;11
3.2;Indirect Methods;13
3.3;Non-InvasiveMethods;15
3.4;Present and Prospective Views on Skin Imaging;19
3.5;References;19
4;In vivo Proton Magnetic Resonance Spectroscopy in Human Skin;22
4.1;Materials and Methods;23
4.2;Results;25
4.3;Discussion;28
4.4;Conclusion;28
4.5;References;29
5;Raman Spectroscopy and Skin;30
5.1;Raman Scattering;30
5.2;Instrumentation;32
5.3;Raman Spectra of Skin;33
5.4;FT Raman Spectra;33
5.5;Visible Light Raman Spectra;35
5.6;In vivo Raman Spectra;35
5.7;Conclusions;35
5.8;References;36
6;Optical Coherence Tomography of the Skin1;37
6.1;Method;38
6.2;Results;39
6.3;Discussion;44
6.4;References;47
7;Examination of Stratum corneum Hydration State by Electrical Methods;48
7.1;An Adequate Description and a Reliable Basis;51
7.2;Assessment of Stratum Corneum Hydration;51
7.3;Validity of Estimating Skin Hydration Using Single-Frequency Admittance or Susceptance Measurements;52
7.4;Understanding and Using the Biophysical Basis;55
7.5;References;56
8;Optothermal Measurement of Water Distribution within the Stratum corneum;58
8.1;Apparatus;58
8.2;Theory;60
8.3;Results;63
8.4;Conclusion;69
8.5;References;70
9;An Improved Method for the Measurement of Scalp Sebum;71
9.1;Materials and Methods;72
9.2;Results;74
9.3;Discussion;77
9.4;Conclusion;78
9.5;References;78
10;Mechanical Function of the Skin: State of the Art;79
10.1;General Description of the Instrument;81
10.2;Description of the Recorded Viscoelastic Parameters;81
10.3;Material and Methods;85
10.4;Description of the Elastic and Viscoelastic Properties of the;86
10.5;Human Skin;86
10.6;Conclusions;92
10.7;References;93
11;Thermal Sensory Analyzer;94
11.1;Boon to the Study of C and A Delta Fibers;94
11.2;Methods of Thermal Sensory Testing;95
11.3;Usefulness of Thermal Sensory Testing;96
11.4;The Future of Thermal Testing;98
11.5;References;99
12;Cutaneous Microdialysis;100
12.1;A New Technique for the Assessment of Skin Penetration;100
12.2;Cutaneous Microdialysis;100
12.3;Trauma after the Insertion of aMicrodialysis Probe into the Skin;103
12.4;In vivo Microdialysis Studies;104
12.5;Applications of Cutaneous Microdialysis;106
12.6;References;107
13;A New Method for Assessing, in vivo in Human Subjects, the Basal or UV- Induced Peroxidation of the Stratum corneum;109
13.1;Application to Test the Efficacy of Free-Radical-Scavenging Products;109
13.2;Material and Methods;110
13.3;Results;112
13.4;Discussion;115
13.5;References;116
14;Biophysical Methods for Disease Monitoring in Dermatology;118
14.1;Psoriasis;119
14.2;Localized Scleroderma;121
14.3;Systemic Sclerosis;122
14.4;Atopic Dermatitis;123
14.5;References;127
15;Skin Bioengineering in Phlebology and Angiology;130
15.1;Capillaroscopy and Fluorescence Video Microscopy;130
15.2;Quantitative Photoplethysmography;133
15.3;VibrationWorkplace Simulator;134
15.4;Local Cold Exposure Tests;136
15.5;Capillary PressureMeasurements;140
15.6;References;142
16;Skin Bioengineering Methods in the Monitoring of Scleroderma;144
16.1;Volunteers, Patients and Methods;145
16.2;Results;148
16.3;Discussion;151
16.4;References;153
17;Skin Bioengineering Methods in Occupational Dermatology;155
17.1;Skin Irritancy Tests;155
17.2;Reproducibility;158
17.3;Correlations between Different Tests;158
17.4;Prevention;158
17.5;Important In.uencing Factors;159
17.6;References;160
18;Climatic Influence on Cosmetic Skin Parameters;161
18.1;Introduction;161
18.2;Material and Methods;161
18.3;Results and Discussion;168
18.4;Conclusion;173
18.5;References;174
19;Lipid Content and Electrical Impedance;175
19.1;Lipid Structure;176
19.2;Electrical Impedance;177
19.3;Test Procedure;179
19.4;Results and Discussion;182
19.5;Conclusion;184
19.6;References;184
20;Evaluation of the Short- Term Effects of Skin C
2;Preface;9
3;Skin Imaging: State of the Art at the Dawn of the Year 2000;11
3.1;Semi-Invasive and Invasive Methods;11
3.2;Indirect Methods;13
3.3;Non-InvasiveMethods;15
3.4;Present and Prospective Views on Skin Imaging;19
3.5;References;19
4;In vivo Proton Magnetic Resonance Spectroscopy in Human Skin;22
4.1;Materials and Methods;23
4.2;Results;25
4.3;Discussion;28
4.4;Conclusion;28
4.5;References;29
5;Raman Spectroscopy and Skin;30
5.1;Raman Scattering;30
5.2;Instrumentation;32
5.3;Raman Spectra of Skin;33
5.4;FT Raman Spectra;33
5.5;Visible Light Raman Spectra;35
5.6;In vivo Raman Spectra;35
5.7;Conclusions;35
5.8;References;36
6;Optical Coherence Tomography of the Skin1;37
6.1;Method;38
6.2;Results;39
6.3;Discussion;44
6.4;References;47
7;Examination of Stratum corneum Hydration State by Electrical Methods;48
7.1;An Adequate Description and a Reliable Basis;51
7.2;Assessment of Stratum Corneum Hydration;51
7.3;Validity of Estimating Skin Hydration Using Single-Frequency Admittance or Susceptance Measurements;52
7.4;Understanding and Using the Biophysical Basis;55
7.5;References;56
8;Optothermal Measurement of Water Distribution within the Stratum corneum;58
8.1;Apparatus;58
8.2;Theory;60
8.3;Results;63
8.4;Conclusion;69
8.5;References;70
9;An Improved Method for the Measurement of Scalp Sebum;71
9.1;Materials and Methods;72
9.2;Results;74
9.3;Discussion;77
9.4;Conclusion;78
9.5;References;78
10;Mechanical Function of the Skin: State of the Art;79
10.1;General Description of the Instrument;81
10.2;Description of the Recorded Viscoelastic Parameters;81
10.3;Material and Methods;85
10.4;Description of the Elastic and Viscoelastic Properties of the;86
10.5;Human Skin;86
10.6;Conclusions;92
10.7;References;93
11;Thermal Sensory Analyzer;94
11.1;Boon to the Study of C and A Delta Fibers;94
11.2;Methods of Thermal Sensory Testing;95
11.3;Usefulness of Thermal Sensory Testing;96
11.4;The Future of Thermal Testing;98
11.5;References;99
12;Cutaneous Microdialysis;100
12.1;A New Technique for the Assessment of Skin Penetration;100
12.2;Cutaneous Microdialysis;100
12.3;Trauma after the Insertion of aMicrodialysis Probe into the Skin;103
12.4;In vivo Microdialysis Studies;104
12.5;Applications of Cutaneous Microdialysis;106
12.6;References;107
13;A New Method for Assessing, in vivo in Human Subjects, the Basal or UV- Induced Peroxidation of the Stratum corneum;109
13.1;Application to Test the Efficacy of Free-Radical-Scavenging Products;109
13.2;Material and Methods;110
13.3;Results;112
13.4;Discussion;115
13.5;References;116
14;Biophysical Methods for Disease Monitoring in Dermatology;118
14.1;Psoriasis;119
14.2;Localized Scleroderma;121
14.3;Systemic Sclerosis;122
14.4;Atopic Dermatitis;123
14.5;References;127
15;Skin Bioengineering in Phlebology and Angiology;130
15.1;Capillaroscopy and Fluorescence Video Microscopy;130
15.2;Quantitative Photoplethysmography;133
15.3;VibrationWorkplace Simulator;134
15.4;Local Cold Exposure Tests;136
15.5;Capillary PressureMeasurements;140
15.6;References;142
16;Skin Bioengineering Methods in the Monitoring of Scleroderma;144
16.1;Volunteers, Patients and Methods;145
16.2;Results;148
16.3;Discussion;151
16.4;References;153
17;Skin Bioengineering Methods in Occupational Dermatology;155
17.1;Skin Irritancy Tests;155
17.2;Reproducibility;158
17.3;Correlations between Different Tests;158
17.4;Prevention;158
17.5;Important In.uencing Factors;159
17.6;References;160
18;Climatic Influence on Cosmetic Skin Parameters;161
18.1;Introduction;161
18.2;Material and Methods;161
18.3;Results and Discussion;168
18.4;Conclusion;173
18.5;References;174
19;Lipid Content and Electrical Impedance;175
19.1;Lipid Structure;176
19.2;Electrical Impedance;177
19.3;Test Procedure;179
19.4;Results and Discussion;182
19.5;Conclusion;184
19.6;References;184
20;Evaluation of the Short- Term Effects of Skin C