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High Quality Content by WIKIPEDIA articles! The skin is the outer covering of the body. In humans, it is the largest organ of the integumentary system made up of multiple layers of ectodermal tissue, and guards the underlying muscles, bones, ligaments and internal organs. Skin of a different nature exists in amphibians, reptiles, birds. Human skin is not unlike that of most other mammals except that it is not protected by a pelt and appears hairless though in fact nearly all human skin is covered with hair follicles. The adjective cutaneous literally means "of the skin".