The most complete reference work available on the subject, Sleisenger and Fordtran's Gastrointestinal and Liver Disease, this Edition provides a balanced, detailed account of the basic science of the digestive system, as well as complete coverage of current diagnosis and management. Readers will find up-to-date discussions of the cell biology and molecular biology that determine the digestive system's function, in addition to thorough descriptions of organ physiology and the pathophysiology of the signs, symptoms and laboratory abnormalities of organ disease. This revision has been brought completely up to date with a new main editor, new authors, and new editors specialising in imaging and pathology.