Small-Molecule Transcription Factor Inhibitors in Oncology

Herausgeber: Rahman, Khondaker Miraz; Thurston, David

• Gebundenes Buch

Produktbeschreibung

Oncogenic transcription factors are an increasingly important target for anticancer therapies. Inhibiting these transcription factors could allow tumour cells to be "reprogrammed", leading to apoptosis or differentiation from the malignant phenotype. As the use of kinase inhibitors is gradually declining, transcription factor inhibition is the next hot topic for oncology research and merits much attention. Small-Molecule Transcription Factor Inhibitors in Oncology highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors. It also presents the evidence that this important protein class can be modulated in a number of ways to develop novel classes of therapeutic agents. Covering both protein-protein and protein-DNA interactions of small-molecule transcription factor inhibition, as well as chemical tools to develop small-molecule transcription factor inhibitors, the broad range of aspects brought together renders this book enormously valuable. This title serves as a unique reference book for postgraduates, academic researchers and practitioners working in the fields of biochemistry, biotechnology, cell and molecular biology and bio-inorganic chemistry.

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Produktdetails

• Verlag: RSC Publishing
• Seitenzahl: 213
• Erscheinungstermin: 6. September 2018
• Englisch
• Abmessung: 234mm x 165mm x 15mm
• Gewicht: 454g
• ISBN-13: 9781782621454
• ISBN-10: 1782621458
• Artikelnr.: 45061746

Inhaltsangabe

Preface: Small Molecule Transcription Factor Inhibitors; Synthetic
Approaches and Challenges Towards Transcription Factor Inhibitors;
Computational Approaches in the Development of Small Molecule Transcription
Factor Inhibitors; Natural Products as Promising Leads Against Oncogenic
Transcription Factors and Associated Signalling Pathways;
Pyrrolobenzodiazepines as Transcription Factor Inhibitors: An Overview;
Small Molecule Inhibitors of NF-kB and Their Therapeutic Potential in
Leukaemia; Targeting Signal Transducer and Activator of Transcription
(STAT) 3 with Small Molecules; Targeting Promoter G-Quadruplexes for
Transcriptional Control