Andere Kunden interessierten sich auch für
![Management of an abdominal aortic aneurysm patient]( "Management of an abdominal aortic aneurysm patient")
Management of an abdominal aortic aneurysm patient29,99 €![Abdominal aortic aneurysm]( "Abdominal aortic aneurysm")
Abdominal aortic aneurysm22,99 €![Current Status of Open Retroperitoneal Aortic Aneurysm Repair]( "Current Status of Open Retroperitoneal Aortic Aneurysm Repair")
Current Status of Open Retroperitoneal Aortic Aneurysm Repair26,99 €![Aortic aneurysms of inflammatory origin]( "Aortic aneurysms of inflammatory origin")
Aortic aneurysms of inflammatory origin29,99 €![BENTALL Surgery for the Treatment of Ascending Aortic Aneurysm]( "BENTALL Surgery for the Treatment of Ascending Aortic Aneurysm")
BENTALL Surgery for the Treatment of Ascending Aortic Aneurysm26,99 €![Prevalence of aortic aneurysms at abdominal ultrasound]( "Prevalence of aortic aneurysms at abdominal ultrasound")
Prevalence of aortic aneurysms at abdominal ultrasound26,99 €![Experience with the Ovation Endograft in abdominal aortic disease]( "Experience with the Ovation Endograft in abdominal aortic disease")
Experience with the Ovation Endograft in abdominal aortic disease26,99 €
Abdominal aortic aneurysm (AAA) is an increasingly common vascular disease affecting 2-9% of elderly people aged more than 65 years. Smoking has been considered an important risk factor associated with AAA development but the pathophysiological mechanisms which underly its adverse effects are uncertain. This project confirm previously reported AAA pathological characteristics namely a decrease in number of elastic lamellae, increased macrophage infiltration, decrease in VSMC density and increase of activity of proteases (MMP-2, MMP-9, MMP-12 and elastase). Cigarette smoking however, was associated with an increasing degree of elastin breakdown, macrophage infiltration and extent of MMP-12 activity in the aortic wall as well as increased plasma MMP-2 and elastase levels. The results support a direct relationship between the level of smoking and the extent of aneurysm aortic wall damage.