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Venoms of viperid and crotalid snakes are rich sources of components that can affect haemostasis by causing changes in blood coagulation and platelet function. Venom components affecting the clotting system include thrombin-like enzymes (TLE) which convert fibrinogen to fibrin, and activators of prothrombin, factor V and factor X. Platelet function can be affected by venom components such as hemorrhagic metalloproteinases, phospholipases. As a result, it is common to find consumption of clotting factors and blood incoagulability accompanied by hemorrhage in victims of snake bite
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