Social intolerance creates an avoidant and unwilling attitude toward ideas that are dissimilar, leading to emotional dys-regulation and psychological distress. The research investigated the relationship of social intolerance and psychological distress moderated by emotional regulation among cardiac patients. Main differences were computed for gender, family system, age, cardiac issues, duration of illness, and physical illness on study variables of social intolerance, emotional regulation and psychological distress. The result of moderating effect of emotional regulation yielded that emotional reappraisal was significant moderator between achievement frustration and psychological distress (anxiety), and entitlement and psychological distress (stress). Emotional reappraisal moderated between achievement frustration and psychological distress (anxiety) whereas emotional reappraisal also moderated in the relationship between entitlement and psychological distress (stress). The book highlighted the role of emotions that play a significant role in better adaptation and emotional dealing of the cardiac patients in bigoted and inevitable situations.