Herchulez

Sodium-Calcium Exchange and the Plasma Membrane Ca2+-Atpase in Cell Function

Fifth International Conference, Volume 1099
Herausgeber: Herchuelz, Andre; Philipson, Kenneth D; Lytton, Jonathan; Blaustein, Mordecai P

• Broschiertes Buch

Produktbeschreibung

Ca2+ homeostasis and the plasma membrane Na+/Ca2+ exchanger are vital to many cellular functions and physiological processes. This volume, which is the proceedings of the fifth in a series of international conferences, includes contributions that merge molecular biology, biochemistry, biophysics, and physiology, providing novel insights that significantly advance our understanding of Na+/Ca2+ exchanger in areas ranging from molecular mechanisms to the involvement in human disease. Several important themes are addressed: (1) structure-function relationships of the exchanger; (2) regulation of the exchanger; (3) Na/Ca exchanger gene regulation; (4) cellular location and targeting of the exchanger; (5) NC(K)X and PMCA KO mice; (6) Na/Ca exchanger interactions with other proteins; (7) Na/Ca exchange in cardiac function; (8) Na/Ca exchange in neuronal function; (9) Ca2+-extruding mechanisms and apoptosis; (10) Na/Ca exchange in smooth muscle, kidney, and endocrine function; (11) Na/Ca exchange inhibitors: therapeutic opportunities. Experts in the field of the plasma membrane Ca2+-ATPase (PMCA) have also contributed. The rate of progress in this field has been rapidly increasing, and new concepts have emerged regarding the relation between molecular structure and physiological function. New ideas on physiological modes of regulation have been increasingly testable through the use of transgenic animal models. This volume and the conference that preceded it continue the tradition of sharing information to fuel new advances in this exciting and important area of research. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Wiley
• Seitenzahl: 400
• Erscheinungstermin: 23. April 2007
• Englisch
• Abmessung: 231mm x 155mm x 22mm
• Gewicht: 907g
• ISBN-13: 9781573316491
• ISBN-10: 1573316490
• Artikelnr.: 22736490

Autorenporträt

Andre Herchuelz and Mordecai P. Blaustein are the authors of Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function: Fifth International Conference, Volume 1099, published by Wiley.

Inhaltsangabe

Preface: Andre Herchuelz. Historical Note Regarding the Discovery of the Na/Ca Exchanger and the PMCA: Andre Herchuelz. Part I: Structure-Function Relationships of the Exchanger:. 1. What We Know about the Structure of NCX1 and How It Relates to Its Function: Debora A. Nicoll
Xiaoyan Ren
Michela Ottolia
Martin Phillips
Alfredo R. Paredes
Jeff Abramson
and Kenneth D. Philipson. 2. Structural Basis for Ca2+ Regulation in the Na+/Ca2+ Exchanger: Mark Hilge
Jan Aelen
Anastassis Perrakis
and Andgeerten W. Vuister. 3. Structure-Function Relationships of the NCKX2 Na+/Ca2+-K+ Exchanger: Y. Shibukawa
K.J. Kang
T.G. Kinjo
R.T. Szerencsei
H.F. Altimimi
P. Pratikhya
R.J. Winkfein
and P.P.M. Schnetkamp. 4. Examining Ca2+ Extrusion of Na+/Ca2+-K+ Exchangers: Haider F. Altimimi and Paul P.M. Schnetkamp. 5. Topologic Investigation of the NCKX2 Na+/Ca2+-K+ Exchanger ¿-Repeats: Tashi G. Kinjo
Robert T. Szerencsei
and Paul P.M. Schnetkamp. 6. Transmembrane Segments I
II
and VI of the Canine Cardiac Na+/Ca2+ Exchanger Are in Proximity: Xiaoyan Ren
Debora A. Nicoll
and Kenneth D. Philipson. 7. Effect of Ca2+ on Protein Kinase A-Mediated Phosphorylation of a Specific Serine Residue in an Expressed Peptide Containing the Ca2+-Regulatory Domain of Scallop Muscle Na+/Ca2+ Exchanger: C. Ryan
G. Shaw
and P.M.D. Hardwicke. Part II. Regulation of the Exchanger:. 8. Regulation of the Cardiac Na+/Ca2+ Exchanger by Calcineurin and Protein Kinase C: Munekazu Shigekawa
Yuki Katanosaka
and Andshigeo Wakabayashi. 9. New Modes of Exchanger Regulation: Physiological Implications: John P. Reeves
Madalina Condrescu
Jason Urbanczyk
and Olga Chernysh. 10. Shedding Light on the Na+/Ca2+ Exchanger: Michela Ottolia
Scott John
Yi Xie
Xiaoyan Ren
and Kenneth D. Philipson. 11. The Regulation of the Na/Ca Exchanger and Plasmalemmal Ca2+ ATPase by Other Proteins: Abdul M. Ruknudin and Edward G. Lakatta. 12. Phosphorylation and Other Conundrums of Na/Ca Exchanger
NCX1: Abdul M. Ruknudin
Shao-Kui Wei
Mark C. Haigney
W.J. Lederer
and Dan H. Schulze. 13. Regulation of Cardiac Na+/Ca2+ Exchanger by Phospholemman: Joseph Y. Cheung
Lawrence I. Rothblum
J. Randall Moorman
Amy L. Tucker
Jianliang Song
Belinda A. Ahlers
Lois L. Carl
Ju Fang Wang
and Xue-Qian Zhang. 14. The Squid Preparation as a General Model for Ionic and Metabolic Na+/Ca2+ Exchange Interactions: Physiopathological Implications: R. Dipolo and L. Beauge. 15. Some Biochemical Properties of the Upregulation of the Squid Nerve Na+/Ca2+ Exchanger by MgATP and Phosphoarginine: Graciela Berberian
Reinaldo Dipolo
and Luis Beauge. 16. Ionic Selectivity of NCKX2
NCKX3
and NCKX4 for Monovalent Cations at K+-Binding Site: Ju-Young Lee
Won-Kyung Ho
and Suk-Ho Lee. 17. In Bovine Heart Na+/Ca2+ Exchanger Maximal Ca2+ i Affinity Requires Simultaneously High pHi and PtdIns-4
5-P2 Binding to the Carrier: Velia Posada
Luis Beauge
and Graciela Berberian. 18. NCX Current in the Murine Embryonic Heart: Development-Dependent Regulation by Na+: Michael Reppel
Hannes Reuter
Philipp Sasse
Jurgen Hescheler
and Bernd K. Fleischmann. 19. Gender Differences in Na/Ca Exchanger Current and ß-Adrenergic Responsiveness in Heart Failure in Pig Myocytes: Shao-Kui Wei
John M. McCurley
Stephen U. Hanlon
and Mark C.P. Haigney. 20. Roles of NCX and PMCA in Basolateral Calcium Export Associated with Mineralization Cycles and Cold Acclimation in Crayfish: M.G. Wheatly
Y. Gao
L.M. Stiner
D.R. Whalen
M. Nade
F. Vigo
and A.E. Golshani. Part III: Na/Ca Exchanger Gene Regulation:. 21. Modulation Pathways of NCX mRNA Stability: Involvement of RhoB: Sachiko Maeda
Isao Matsuoka
and Junko Kimura. 22. Regulation of Ncx1 Gene Expression in the Normal and Hypertrophic Heart: Donald R. Menick
Ludivine Renaud
Avery Buchholz
Joachim G. Muller
Hongming Zhou
Christiana S. Kappler
Steven W. Kubalak
Simon J. Conway
and Lin Xu. 23. Cyclosporin A-Dependent Downregulation of the Na+/Ca2+ Exchanger Expression: H. Rahamimoff
B. Elbaz
A. Alperovich
C. Kimchi-Sarfaty
M.M. Gottesman
Y. Lichtenstein
M. Eskin-Shwartz
and J. Kasir. Part IV: Cellular Location of the Exchanger:. 24. Functional Significance of Na+/Ca2+ Exchangers Co-localization with Ryanodine Receptors: Anna A. Sher
Robert Hinch
Penelope J. Noble
David J. Gavaghan and Denis Noble. 25. Three Types of Muscles Express Three Sodium-Calcium Exchanger Isoforms: Dmitri O. Levitsky. Part V: Structure-Function Relationship of the Plasma Membrane Ca2+-ATPase:. 26. Plasma Membrane Ca2+ ATPases as Dynamic Regulators of Cellular Calcium Handling: Emanuel E. Strehler
Ariel J. Caride
Adelaida G. Filoteo
Yuning Xiong
John T. Penniston
and Agnes Enyedi. 27. Functional Specificity of PMCA Isoforms?: Teuta Domi
Francesca Di Leva
Laura Fedrizzi
Alessandro Rimessi
and Marisa Brini. 28. Plasma Membrane Calcium ATPase and Its Relationship to Nitric Oxide Signaling in the Heart: Elizabeth J. Cartwright
Delvac Oceandy
and Ludwig Neyses. 29. Functional Importance of PMCA Isoforms in Growth and Development of PC12 Cells: Ludmila Zylinska
Anna Kozaczuk
Janusz Szemraj
Christos Kargas
and Iwona Kowalska. Part VI: NC(K)X and PMCA KO Mice:. 30. Na+/Ca2+ Exchanger Knockout Mice: Plasticity of Cardiac Excitation-Contraction Coupling: Christian Pott
Scott A. Henderson
Joshua I. Goldhaber
and Kenneth D. Philipson. 31. Distinct Phenotypes among Plasma Membrane Ca2+-ATPase Knockout Mice: Vikram Prasad
Gbolahan Okunade
Li Liu
Richard J. Paul
and Gary E. Shull. 32. Role of Plasma Membrane Calcium ATPase Isoform 2 in Neuronal Function in the Cerebellum and Spinal Cord: Michael P. Kurnellas
Amanda K. Lee
Karolynn Szczepanowski
and Stella Elkabes. 33. Increased Tolerance to Ischemic Neuronal Damage by Knockdown of Na+-Ca2+ Exchanger Isoform 1: Jing Luo
Yanping Wang
Xinzhi Chen
Hai Chen
Douglas B. Kintner
Gary E. Shull
Kenneth D. Philipson
and Dandan Sun. 34. Resistance of Cardiac Cells to NCX Knockout: A Model Study: Denis Noble
Nobuaki Sarai
Penelope J. Noble
Tsutomu Kobayashi
Satoshi Matsuoka
and Akinori Noma. 35. Homozygous Overexpression of the Na+-Ca2+ Exchanger in Mice: Evidence for Increased Transsarcolemmal Ca2+ Fluxes: Christian Pott
Joshua I. Goldhaber
and Kenneth D. Philipson. Part VII. Cardiac Function:. 36. Na/Ca Exchange: Regulator of Intracellular Calcium and Source of Arrhythmias in the Heart: L.A. Venetucci
A.W. Trafford
S.C. O'Neill
and D.A. Eisner. 37. Na:Ca Stoichiometry and Cytosolic Ca-Dependent Activation of NCX in Intact Cardiomyocytes: Donald M. Bers and Kenneth S. Ginsburg. 38. Na/Ca Exchange and Cardiac Ventricular Arrhythmias: Karin R. Sipido
V. Bito
G. Antoons
Paul G. Volders
and Marc A. Vos. 39. The Role of the Cardiac Na+/Ca2+ Exchanger in Reverse Remodeling: Relevance for LVAD-Recovery: Cesare M.N. Terracciano
Maren U. Koban
Gopal K. Soppa
Urszula Siedlecka
Joon Lee
Mark A. Stagg
and Magdi H. Yacoub. 40. Regulation of Na+/Ca2+ Exchange Current in the Normal and Failing Heart: Michael Reppel
Bernd K. Fleischmann
Hannes Reuter
Frank Pillekamp
Heribert Schunkert
and Jurgen Hescheler. 41. Phosphorylation of Na+/Ca2+ Exchanger in TAB-Induced Cardiac Hypertrophy: Yuki Katanosaka
Bongju Kim
Shigeo Wakabayashi
Satoshi Matsuoka
And Munekazu Shigekawa. 42. Role of Ca2+ Transporters and Channels in the Cardiac Cell Volume Regulation: A. Takeuchi
S. Tatsumi
N. Sarai
K. Terashima
S. Matsuoka
and A. Noma. Part VIII: NCX and PMCA in Neuronal and Smooth Muscle Function:. 43. NCX and NCKX Operation in Ischemic Neurons: Lech Kiedrowski. 44. Na+/Ca2+ Exchange and Ca2+ Homeostasis in Axon Terminals of Mammalian Central Neurons: Suk-Ho Lee
Myoung-Hwan Kim
Ju-Young Lee
Sang Hun Lee
Doyun Lee
Kyeong Han Park
and Won-Kyung Ho. 45. ncx1
ncx2
and ncx3 Gene Product Expression and Function in Neuronal Anoxia and Brain Ischemia: L. Annunziato
G. Pignataro
F. Boscia
R. Sirabella
L. Formisano
M. Saggese
O. Cuomo
R. Gala
A. Secondo
D. Viggiano
P. Molinaro
V. Valsecchi
A. Tortiglione
A. Adornetto
A. Scorziello
M. Cataldi
and G.F. Di Renzo. 46. Sodium-Calcium Exchanger in Pulmonary Artery Smooth Muscle Cells: Yun-Min Zheng and Yong-Xiao Wang. 47. Rapid Downregulation of NCX and PMCA in Hippocampal Neurons Following H2O2 Oxidative Stress: Sertac N. Kip and Emanuel E. Strehler. Part IX: Ca2+ Extruding Mechanisms and Apoptosis:. 48. Cleavage of the Plasma Membrane Ca2+ATPase during Apoptosis: Katalin Paszty
Geza Antalffy
Luca Hegedus
Rita Padanyi
Alan R. Penheiter
Adelaida G. Filoteo
John T. Penniston
and Agnes Enyedi. 49. The Plasma Membrane Na+/Ca2+ Exchanger Is Cleaved by Distinct Protease Families in Neuronal Cell Death: D. Bano
E. Munarriz
H.L. Chen
E. Ziviani
G. Lippi
K.W. Young
and P. Nicotera. 50. Role of Na/Ca Exchange and the Plasma Membrane Ca2+-ATPase in ß Cell Function and Death: Andre Herchuelz
Adama Kamagate
Helena Ximenes
and Francoise Van Eylen. 51. Overexpression of Na/Ca Exchanger Reduces Viability and Proliferation of Gliosarcoma Cells: Evrard Nguidjoe and Andre Herchuelz. 52. Redox Modulation of the Apoptogenic Activity of Thapsigargin: Claudia Cerella
Simona Coppola
Maria D'Alessio
Milena De Nicola
Andrea Magrini
Antonio Bergamaschi
and Lina Ghibelli. 53. The Role of Na+/Ca+ Exchanger in Endothelin-1-Aggravated Hypoxia/Reoxygenation-Induced Injury in Renal Epithelial Cells: Satomi Kita
Ayako Furuta
Yukio Takano
and Takahiro Iwamoto. 54. Involvement of Na+/Ca2+ Exchanger Type-1 in Ischemia-Induced Neovascularization in the Mouse Hindlimb: Yukiko Matsui
Satomi Kita
Takeshi Katsuragi
Issei Komuro
Takahiro Iwamoto
and Hiroyuki Ohjimi. 55. The Na+/Ca2+ Exchanger Isoform 3 (NCX3) but Not Isoform 2 (NCX2) and 1 (NCX1) Singly Transfected in BHK Cells Plays a Protective Role in a Model of in Vitro Hypoxia: Agnese Secondo
Ilaria Rosaria Staiano
Antonella Scorziello
Rossana Sirabella
Francesca Boscia
Annagrazia Adornetto
Lorella Maria Teresa Canzoniero
Gianfranco Di Renzo
and Lucio Annunziato. 56. Involvement of the Potassium-Dependent Sodium/Calcium Exchanger Gene Product NCKX2 in the Brain Insult Induced by Permanent Focal Cerebral Ischemia: Ornella Cuomo
Giuseppe Pignataro
Rosaria Gala
Francesca Boscia
Anna Tortiglione
Pasquale Molinaro
Gianfranco Di Renzo
Jonathan Lytton
Andlucio Annunziato. Part X: Na/Ca Exchange in the Endoplasmic Reticulum
the Mitochondria
and the Nuclear Envelope:. 57. Analysis of Calcium Changes in Endoplasmic Reticulum during Apoptosis by the Fluorescent Indicator Chlortetracycline: Claudia Cerella
Cristina Mearelli
Milena De Nicola
Maria D'Alessio
Andrea Magrini
Antonio Bergamaschi
and Lina Ghibelli. 58. Sodium-Calcium Exchangers in the Nucleus: An Unexpected Locus and an Unusual Regulatory Mechanism: Robert W. Ledeen and Gusheng Wu. 59. Mitochondrial Ca2+ Flux through Na+/Ca2+ Exchange: Bongju Kim and Satoshi Matsuoka. 60. Non-apoptogenic Ca2+-Related Extrusion of Mitochondria in Anoxia/Reoxygenation Stress: Annalisa Dorio
Claudia Cerella
Milena De Nicola
Maria D'Alessio
Giampiero Gualandi
and Lina Ghibelli. Part XI. Na/Ca Exchange Inhibitors: Therapeutic Opportunities:. 61. Na+/Ca2+ Exchange as a Drug Target-Insights from Molecular Pharmacology and Genetic Engineering: Takahiro Iwamoto. 62. Inhibitory Mechanism of SN-6
A Novel Benzyloxyphenyl Na+/Ca2+ Exchange Inhibitor: Satomi Kita and Takahiro Iwamoto. 63. Electrophysiological Effects of SN-6
a Novel Na+/Ca2+ Exchange Inhibitor on Membrane Currents in Guinea Pig Ventricular Myocytes: Chun-Feng Niu
Yasuhide Watanabe
Takahiro Iwamoto
Kanna Yamashita
Hiroshi Satoh
Tuyoshi Urushida
Hideharu Hayashi
and Junko Kimura. Position Paper. 64. Directionality in Drug Action on Sodium-Calcium Exchange: D. Noble And M. P. Blaustein. Index of Contributors