Soft Condensed Matter Physics in Molecular and Cell Biology

Herausgeber: Andelman, David; Poon, W. C. K.

• Gebundenes Buch

Produktbeschreibung

Soft condensed matter physics, which emerged as a distinct branch of physics in the 1990s, studies complex fluids: liquids in which structures with length scale between the molecular and the macroscopic exist. Polymers, liquid crystals, surfactant solutions, and colloids fall into this category. Physicists deal with properties of soft matter systems that are generic and largely independent of chemical details. They are especially fascinated by the way soft matter systems can harness Brownian motion to self-assemble into higher-order structures. Exploring the generic properties of soft matter offers insights into many fundamental questions that cut across a number of disciplines. Although many of these apply to materials and industrial applications, the focus of this volume is on their applications in molecular and cell biology based on the realization that biology is soft matter come alive. The chapters in Soft Condensed Matter Physics in Molecular and Cell Biology originated as lectures in the NATO Advanced Science Institute (ASI) and Scottish Universities Summer Schools in Physics with the same name; they represent the thinking of seventeen experts operating at the cutting edge of their respective fields. The book provides a thorough grounding in the fundamental physics of soft matter and then explores its application with regard to the three important classes of biomacromolecules: proteins, DNA, and lipids, as well as to aspects of the biology of cells. The final section of the book considers experimental techniques, covering single molecule force spectroscopy of proteins, the use of optical tweezers, along with X-ray, neutron, and light scattering from solutions. While this work presents fundamentals that make it a suitable text for graduate students in physics, it also offers valuable insights for established soft condensed matter physicists seeking to contribute to biology, and for biologists wanting to understand what the latest think

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 340
• Erscheinungstermin: 13. Januar 2006
• Englisch
• Abmessung: 240mm x 161mm x 23mm
• Gewicht: 677g
• ISBN-13: 9780750310239
• ISBN-10: 0750310235
• Artikelnr.: 21840754

Autorenporträt

W. C. K. Poon, D. Andelman

Inhaltsangabe

INTRODUCTION: Coarse graining in biological soft matter The atomistic
description of globular proteins: the tertiary structure Coarse-graining :
level 1 Secondary structure; Coarse-graining : level 2 Domains
Coarse-graining : level 3 Proteins as colloids Further coarse-graining I.
SOFT MATTER BACKGROUND Introduction to colloidal systems Colloidal phase
behaviour; Colloid dynamics The physics of floppy polymers Statistical
physics of single chains Statistical physics of many chains Polymer
dynamics Self-assembly and properties of lipid membranes The constituents
of lipid bilayer membranes Self assembly Bilayer membrane phases Membrane
energies Fluctuations Domains, shapes and other current issues Some aspects
of membrane elasticity Gibbs' description Description in terms of
microscopic properties Equations of equilibrium and shape of interfaces
Introduction to electrostatics in soft and biological matter The
Poisson-Boltzmann theory Poisson-Boltzmann equation: planar geometry;
Poisson-Boltzmann equation: cylindrical coordinates; Poisson-Boltzmann
equation: spherical coordinates -- Charged colloids Beyond the
Poisson-Boltzmann treatment Thermal Barrier Hopping in Biological Physics A
preliminary: Diffusion on a flat landscape First passage times: an exact
result Landscapes and intermediate states Higher-dimensional barrier
crossing II. BIOLOGICAL APPLICATIONS Elasticity and dynamics of
cytoskeletal filaments and their networks Single-filament properties
Solutions of semi-flexible polymer Network elasticity Nonlinear response
Twisting and stretching DNA: Single-molecule studies Micromanipulation
techniques Stretching DNA DNA under torsion DNA-protein interactions
Interactions and conformational fluctuations in DNA arrays Electrostatic
interactions Equation of state: No thermal fluctuations; Effect of thermal
fluctuations (1) Effect of thermal fluctuations (2) Sequence-structure
relationships in proteins Energy functions for fold recognition The
evolutionary capacity of