Amit Vishwakarma

Solid Self Micron Emulsifying Drug Delivery System of Rosuvastatin

Noval Drug Delivery System (SSMEDDS) - Rosuvastatin Calcium

• Broschiertes Buch

Produktbeschreibung

The objective of present research work was to develop a self-emulsifying drug delivery system of Rosuvastatin Calcium (RC) for increasing its solubility, and oral bioavailability. Solubility of RC was determined in various vehicles. Oil, Surfactant and Cosurfactant were selected based on the solubility and HLB (Hydrophilic lipophilic balance) value. To identify the microemulsion existing zone Pseudo-ternary phase diagrams were constructed. Solubility analysis was also done for optimization of formulation. The optimised microemulsion formulation was evaluated for Powder X-Ray Diffraction (XRD), SEM (Scanning electron microscopy) analysis, globule size, zeta potential and phase separation study. Average globule size and zeta potential of the optimized microemulsion formulation were found to be 30 nm, and -11.5 mV, respectively. The viscosity and conductivity data indicated that the microemulsion was of the o/w type.The solubility of RC was successfully enhanced up to 82.32%. Percent drug release at the end of 60 min was found to be 76.74 %. The solubility of Rosuvastatin Calcium was significantly enhanced after formulating into self-emulsify microemulsion.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 92
• Erscheinungstermin: 30. April 2020
• Englisch
• Abmessung: 220mm x 150mm x 7mm
• Gewicht: 155g
• ISBN-13: 9786139912087
• ISBN-10: 6139912083
• Artikelnr.: 59509759

Autorenporträt

-Amit Kumar VishwakarmaMaster of Pharmacy in Pharmaceutics from Amity University Uttar Pradesh, Lucknow.7 publication in indexed journals.Professional Experience6 yrs of rich experience in diabetes and metabolism therapy area while working in Medical Affairs and Medico Marketing role in large multinational companies.