SOLUBILITY ENHANCEMENT OF NISOLDIPINE BY SPHERICAL CRYSTALLIZATION - VISHNU, Y VAMSHI;SAMREEN, SANA
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The result of phase solubility studies revealed that there is enhancement of solubility by Carrageenan. Rod shaped crystals of pure drug converted to spherical was confirmed by opticalmicroscopy. The dissolution of agglomerates of optimum batch exhibited 98.27% release compare to 39.60% of pure drug within 120 minute This study demonstrated that spherical crystallization technique can be considered as a suitable alteration of granulation. Nisoldipine spherical agglomerates can be prepared with Carrageenan. It exhibited excellent physicochemical, solubility, dissolution rate in comparison with…mehr

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Produktbeschreibung
The result of phase solubility studies revealed that there is enhancement of solubility by Carrageenan. Rod shaped crystals of pure drug converted to spherical was confirmed by opticalmicroscopy. The dissolution of agglomerates of optimum batch exhibited 98.27% release compare to 39.60% of pure drug within 120 minute This study demonstrated that spherical crystallization technique can be considered as a suitable alteration of granulation. Nisoldipine spherical agglomerates can be prepared with Carrageenan. It exhibited excellent physicochemical, solubility, dissolution rate in comparison with pure drug. Among other spherical crystallization technique, QESD proved to be excellent technique for enhancement of solubility and dissolution.
Autorenporträt
Research of interest in the field of novel & smart drug delivery systems and published 45 international & 6 national journals & visited 2 university in U.S.A. Attended various international & national conferences.Write various book chapters for various book publishers. Reviewer for various journal. Guided 102 PG students and 4 Ph.D fellows.