Some novel 1, 4-thiazepine derivatives - Sarveswari, S.
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The 1, 4-thiazepine fused derivatives were synthesized by L-proline catalyzed one-pot mechanistic pathway. Though L-proline is being amphoteric molecule with both amine end carboxylic acid end, it worked as an enamine base for the catalysis. We aim to synthesize organic molecules with anti-cancer activity. This protocol provides a synthetic route for the efficient synthesis of 1, 4 -thiazepines. All the synthesized molecules were screened for the cytotoxicity studies. We have screened the synthesized 1, 4-thiazepines against to six cell lines, namely 'Pancreas (PANC1), Renal (ACHN), Colon…mehr

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Produktbeschreibung
The 1, 4-thiazepine fused derivatives were synthesized by L-proline catalyzed one-pot mechanistic pathway. Though L-proline is being amphoteric molecule with both amine end carboxylic acid end, it worked as an enamine base for the catalysis. We aim to synthesize organic molecules with anti-cancer activity. This protocol provides a synthetic route for the efficient synthesis of 1, 4 -thiazepines. All the synthesized molecules were screened for the cytotoxicity studies. We have screened the synthesized 1, 4-thiazepines against to six cell lines, namely 'Pancreas (PANC1), Renal (ACHN), Colon (HCT116), Non-small cell lung (H460), Lung (CALUl) and Normal breast epithelium (MCF10A)' with two concentration 1miM and 10miM concentration levels.
Autorenporträt
Dr. S. Sarveswari arbeitet auf dem Gebiet der Synthese, der Sensoren und des Screenings medizinischer Aktivitäten.