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Diabetes mellitus is an important endocrine disorder and is causing health problems in many countries. According to the available data overall 6.9 million people Pakistan are affected with diabetes, whereas WHO has ranked Pakistan as 7th on diabetes prevalence day. The International Diabetes Federation has given some predictions that by 2030 the 366 million people with diabetes will increase to 522 million. Dietary supplementation of soy isoflavone has been given promising results regarding altering glycemic level, and insulin resistance in post-menopausal diabetic women with type 2 diabetes. Soy isoflavone has a constructive and straight effect on controlling diabetes. Recent study explored the hypoglycemic effect of soy isoflavone in post-menopausal diabetic women. Fifteen diabetic post-menopausal women were fed on 60 mg/day soy isoflavone at fasting time. The pre-feeding blood glucose and two hours after feeding blood glucose levels of diabetic women were examined daily, whileother bio-chemical assays like blood insulin, liver functioning test, total protein, albumin, globulin, urea and creatinine were determined weekly during the course of the study.