Spaceflight Associated Neuro-Ocular Syndrome

Herausgeber: Lee, Andrew G; Ong, Joshua

• Broschiertes Buch

Produktbeschreibung

Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity-associated findings collectively define the Spaceflight Associated Neuro-ocular Syndrome (SANS). In this book, the editors compare and contrast prior published work on SANS by the National Aeronautics and Space Administration's (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. The book describes the possible mechanisms and potential etiologies for SANS, and provides an update and review on the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). The ocular imaging findings (e.g., retinal nerve fiber layer, optic disc, and choroidal changes on optical coherence tomography) of SANS is also described, including the intraorbital and intracranial findings on orbital ultrasound and magnetic resonance imaging. The knowledge gaps for in-flight and terrestrial human research including potential countermeasures for future stud is also explored, including reports on the in-flight and terrestrial human and animal research being investigated by NASA and its partners to study SANS both prospectively and longitudinally and in preparation for future long duration manned missions to space including the moon, the asteroid belt, or Mars. We think this is a unique topic and hope that NASA and its research partners continue to study SANS in preparation for future longer duration manned space missions.

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Produktdetails

• Verlag: Elsevier Science & Technology
• Seitenzahl: 240
• Erscheinungstermin: 25. Juli 2022
• Englisch
• Abmessung: 242mm x 192mm x 12mm
• Gewicht: 532g
• ISBN-13: 9780323915243
• ISBN-10: 0323915248
• Artikelnr.: 63244000

Inhaltsangabe

1. An introduction to space medicine and the physiological effects of
spaceflight on the human body 2. Neuro-ocular findings and mechanisms in
Spaceflight Associated Neuro-Ocular Syndrome 3. Optical coherence
tomography and Spaceflight Associated Neuro-Ocular Syndrome 4. Clinical
neuroimaging of Spaceflight Associated Neuro-Ocular Syndrome 5. Genetics,
vitamins, and Spaceflight Associated Neuro-Ocular Syndrome 6. Glymphatic
system and Spaceflight Associated Neuro-Ocular Syndrome 7. Mechanical
alterations of the brain and optic chiasm in Spaceflight Associated
Neuro-Ocular Syndrome 8. Intraocular pressure and Spaceflight Associated
Neuro-Ocular Syndrome 9. Intraocular and intracranial pressure
relationships for Spaceflight Associated Neuro-Ocular Syndrome
countermeasures 10. Pathophysiology of cerebral edema and its connection to
Spaceflight Associated Neuro-Ocular Syndrome 11. Cerebral hemodynamic
changes and invasive/noninvasive monitoring for Spaceflight Associated
Neuro-Ocular Syndrome 12. Terrestrial analogs for Spaceflight Associated
Neuro-Ocular Syndrome 13. Potential countermeasures for Spaceflight
Associated Neuro-Ocular 14. Space-induced neuroocular syndrome in
astronautsdthe ICP hypothesis 15. Multimodal assessment of visual function
and ocular structure for monitoring Spaceflight Associated Neuro-Ocular
Syndrome