Gottfried Baier / Burkhart Schraven / Arne von Bonin / Ulrich Zügel (eds.)

Sparking Signals

Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation
Herausgegeben von Baier, Gottfried; Schraven, Burkhart; Zügel, Ulrich; Bonin, Arne von

• Gebundenes Buch

Produktbeschreibung

The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. In this book, well known experts present their most recent findings on the fast developing kinase field. It will be of interest to basic researchers and the pharmaceutical industry.

Produktdetails

• Ernst Schering Foundation Symposium Proceedings 2007/3
• Verlag: Springer, Berlin
• Artikelnr. des Verlages: 12087709
• 2008
• Seitenzahl: 204
• Erscheinungstermin: 11. April 2008
• Englisch
• Abmessung: 241mm x 160mm x 17mm
• Gewicht: 420g
• ISBN-13: 9783540735007
• ISBN-10: 3540735003
• Artikelnr.: 23414162

Inhaltsangabe

Proteomics-bases Strategies in Kinase Drug Discovery.- PKC Isotype Functions in T-Lymphocytes.- Molecular and Systems-Biology Approaches to Define Signaling Pathways in Lymphocytes.- Solving the IRAK-4 Enigma. Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting and Regulating PAMPS.- Migration, Cell-Cell Interaction and Adhesion in the Immune System.- The Role of Diacylglycerol Kinases in T Cell Anergy.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.