SPECTROPHOTOMETRIC AND SPECTROSCOPIC STUDIES OF NOVEL ANTI-CANCER DRUG - Kodadi, Shirish Kumar
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Understanding the charge transfer process between bioactive molecules and inorganic or organic molecules is significant as this interaction can be used to interpret bioactive molecule-receptor interactions. A comprehensive spectrophotometric study has been performed to explore the complexation chemistry of the Crizotinib (CZT) with pi - acceptor. The molecular structure, spectroscopic characteristics and the interactive modes have been deduced from UV-Vis and FT-IR spectra. The binding ratio of complexation has been determined to be 1:1 for acceptor with CZT. Benesi-Hildebrand method was…mehr

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Produktbeschreibung
Understanding the charge transfer process between bioactive molecules and inorganic or organic molecules is significant as this interaction can be used to interpret bioactive molecule-receptor interactions. A comprehensive spectrophotometric study has been performed to explore the complexation chemistry of the Crizotinib (CZT) with pi - acceptor. The molecular structure, spectroscopic characteristics and the interactive modes have been deduced from UV-Vis and FT-IR spectra. The binding ratio of complexation has been determined to be 1:1 for acceptor with CZT. Benesi-Hildebrand method was applied to estimate the spectroscopic and physical data. The association constant (K), extinction coefficient (_max), ionization potential (IP), energy of the charge transfer complex (ECT), resonance energy (RN), dissociation energy (W) and standard Gibbs energy ( G0) have been computed. Based upon the obtained spectroscopic data, the plausible CT mechanism between CZT and acceptor was proposed.
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Autorenporträt
O Dr. K. Shirish Kumar está trabalhando como Professor Associado de Química no Instituto de Tecnologia Vignana Bharathi, Hyderabad, Índia. Ele recebeu o "Prêmio Jovem Pesquisador", o Prêmio de Melhor Professor Universitário e o "Prêmio Internacional de Pesquisador Destacado", é Ph.D. em Química pela Universidade de Osmania.