Spider Venoms
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  • Audio CD mit DVD

This volume provides an overview of the biochemical characterization, structure-function studies, proteomics, bioinformatics, molecular biology, transcriptomics and genomics of various spider species. The book also covers our current knowledge of venom components, toxins and their modes of action. The first section of Spider Venom includes contributions regarding the wide diversity of spider venom components and depicts some of their biological effects (antimicrobial, ion channel modulators, insecticides, this includes peptide and non-peptide toxins), and emphasizes spiders of public health…mehr

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Produktbeschreibung
This volume provides an overview of the biochemical characterization,
structure-function studies, proteomics, bioinformatics, molecular biology,
transcriptomics and genomics of various spider species. The book also covers
our current knowledge of venom components, toxins and their modes of action.
The first section of Spider Venom includes contributions regarding the
wide diversity of spider venom components and depicts some of their biological
effects (antimicrobial, ion channel modulators, insecticides, this includes
peptide and non-peptide toxins), and emphasizes spiders of public health
importance. The second section covers transcriptomes, proteomes (and
peptidomics), bioinformatics and molecular dynamics. The last section describes
antimicrobial, insecticidal toxins, envenomation and the medical potential of
spider venoms.

Spider venoms are a great and extensive source of bioactive compounds,
and as such form a boundless and bountiful area awaiting discovery. It is by
virtue of dedicated scientists that new toxins are discovered and that new
insights arise, leading the way towards the investigation of their
pharmacological effects, and hopefully, as a consequence, arriving at the
discovery of venom components as new drug candidates.
Autorenporträt
Prof P. Gopalakrishnakone is a world leader in the characterization of the structure and function of animal and plant toxins and chemical poisons, which contain highly specific and biologically active components. He has contributed significantly to the body of knowledge regarding the anatomy of snake venom glands and the development of drug candidates from animal toxins.

Prof Gopal pioneered the development of the NUS Venom and Toxin Research Programme, which has put NUS at the forefront of toxin research internationally. The technology platform that has been built over the years under the Venom and Toxin Research Programme, coupled with its extensive library of protein and peptides, has enabled Prof Gopal and his team to complete the discovery process of lead candidates in time and to transfer valuable supplementary information to the next discovery steps involving profiling and optimization of lead candidates. The objective is to characterize the venom components and natural toxins at a molecular level and identify promising compounds amenable to the development of novel human therapeutics. Prof Gopal's lab has identified over twenty peptides with unique medical indications from venom-based proteins with some already under development as therapeutics.

Prof Gopal's research studies includes structure function studies (toxin detection, biosensors, antitoxins and neutralization factors), toxicogenomics and expression studies, antimicrobial peptides from venoms and toxins and PLA2 inhibitors as potential drug candidate for inflammatory diseases. The techniques he employs include quantum dots to toxinology, computational biology, microarrays and protein chips. He has patented analgesic peptide, anti inflammatory peptide as well as anti rheumatoid arthritis peptides. He is exploring various possibilities of delivery systems for these peptides to target sites and administration of these peptides orally, transdermally, ocular and injections.

Prof Gopal has over 100 international peer-reviewed papers in venom and toxin research, drug discovery, biosensors, and toxinogenomics. His research awards include the Outstanding University Researcher Award from the National University of Singapore (1998); Ministerial Citation, NSTB Year 2000 Award in Singapore; and the Research Excellence Award from the Faculty of Medicine, National University of Singapore (2003). His awards in teaching include, Faculty Teaching Excellence Award 2003/4 & NUS Annual Teaching Excellence Award 2003/4. He also received the Faculty Teaching Excellence Award in 2009/10 and the Annual Teaching Excellence Award, NUS FOR 2009/10. He is the President of International Society on Toxinology till 2012, and is a member of the editorial board of Toxicon, the official journal of the International Society on Toxinology.