Adeeb Shehzad

Splicing And Inflammatory Factors In Cancer Survival And Therapy

• Broschiertes Buch

Produktbeschreibung

This book underpins the Prp4 and PGE2-induced cancer cell's survival and underlying mechanism of anti-cancer and radiosensitizing effects of curcumin (a derivative of turmeric) in colorectal carcinoma as well as in B16F10-induced tumor xenograft. Curcumin and ionizing radiation (IR) inhibited HCT-15 cell proliferation, induced apoptosis, and reduced tumor volume in C57BL6/J mice. Transfection of HCT-15 cells with splicing factor Prp4 clone reverses curcumin and IR-induced cell death. However, knockdown of Prp4 with siRNA diminished the protective effects of Prp4 against curcumin and IR-induced apoptosis in HCT-15 cells. Curcumin treatment also restored the IR-induced cell death as well as greatly reduced the tumor volume by regulating the level of antioxidant enzymes. PGE2, an inflammatory mediator, inhibited curcumin-induced oxidative stress apoptosis by regulating survival pathways such as COX-2 and PKA, Ras/Raf/Erk, and NF- B through EP2 receptor. Taken together, splicing factor Prp4 and inflammatory mediator PGE2 enhances the survival as well as protect the cancer cells death by activating the anti-oxidant enzymes, Ras/Raf/Erk, and NF- B pathways.

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Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 144
• Erscheinungstermin: 16. Juni 2020
• Englisch
• Abmessung: 220mm x 150mm x 9mm
• Gewicht: 233g
• ISBN-13: 9786202669702
• ISBN-10: 6202669705
• Artikelnr.: 59831082

Autorenporträt

Adeeb Shehzad obtained his B.Pharmacy from the University of Peshawar, Pakistan in 2003. He completed his MS and Ph.D degree from Kyungpook National University, South Korea (2008¿2014). Since 2015, he is serving as Assistant Professor at the National University of Sciences and Technology, Pakistan. His research mainly focus on cancer chemotherapy.