High Quality Content by WIKIPEDIA articles! The St. Joseph River (locally known as the St. Joe) is a river, approximately 210 mi (338 km) long, in southern Michigan and northern Indiana in the United States. It drains a primarily rural farming area in the watershed of Lake Michigan. It was enormously important in the days of Native Americans and the colonial settlement as a canoe route between Lake Michigan and the watershed of the Mississippi River. The St. Joseph River rises in southern Michigan in Hillsdale County near Baw Beese Lake, within 5 mi (8 km) of the headwaters of the St. Joseph River in the Maumee watershed. It follows a zigzag route generally westward across southern Michigan, dipping into northern Indiana. From its headwaters it flows initially northwest past Hillsdale into southeastern Calhoun County, then turns abruptly southwest to flow past Tekonsha, Union City, and Sherwood.