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State, S&T+I and territorial development in Colombia, presents an overview of the current situation in the country with respect to the role of science, technology and innovation in territorial development. Departments such as Putumayo, Vaupés, Guaviare, among others, have little use of knowledge to favour their endogenous territorial development, due to the scarce use of S&T&I in the business and productive system, non-existence of patents, minimal presence of researchers, low investment in R&D, insufficient number of research groups, among other indicators. On the contrary, Bogotá, Antioquia, the coffee-growing region, Cundinamarca, ... have the human capacities and infrastructure to articulate S&T&I with the economic and industrial dynamics, mainly to favour endogenous territorial development. In this dynamic, the Colombian state plays a fundamental role in solving market failures and systemic failures in order to accelerate the quality of life and social welfare from the perspective of science, technology and innovation.