Statistical Evaluation of Mutagenicity Test Data
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This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. New chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds. Although guidelines exist on the performance of these tests, advice on data evaluation is scarce; this volume provides the statistical background necessary for toxicologists to understand, design and interpret mutagenicity tests. In addition to the nine chapters dealing with the different tests employed, there is an int...
This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. New chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds. Although guidelines exist on the performance of these tests, advice on data evaluation is scarce; this volume provides the statistical background necessary for toxicologists to understand, design and interpret mutagenicity tests. In addition to the nine chapters dealing with the different tests employed, there is an introductory chapter on some of the statistical principles involved, a glossary of useful terms and an appendix providing vital information on the availability of computer software. A large team of contributors and editors working under the auspices of the United Kingdom Environmental Mutagen Society (UKEMS) have contributed a wealth of first-hand experience in compiling this immensely practical book of use to both research and industrial toxicologists.
Table of contents:
Preface; 1. Introduction; 2. Microbial colony assays; 3. Mammalian cell colony assay; 4. Fluctuation tests; 5. In vitro cytogenetics; 6. Sister chromatid exchanges; 7. In vivo cytogenetics; 8. Dominant lethal test; 9. Drosophila; Appendices.
Table of contents:
Preface; 1. Introduction; 2. Microbial colony assays; 3. Mammalian cell colony assay; 4. Fluctuation tests; 5. In vitro cytogenetics; 6. Sister chromatid exchanges; 7. In vivo cytogenetics; 8. Dominant lethal test; 9. Drosophila; Appendices.
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