This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.…mehr
This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.
Preface 1. Introduction 2. Macromolecular stability 3. Lattice dynamics 4. Effective phonon theory 5. Premelting disrupted chemical bonds 6. Co-operative melting 7. Strained chemical bonds: salt and pressure effects 8. Bond disruption and conformation change: B to Z confirmation change in DNA 9. Hydration effects: structural water 10. Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA bonding constant 11. Non repeating DNA 12. Cutting and splicing: junctions, inserts and the replicating fork 13. Interaction between a helix and a single attached molecule 14. Energy considerations in bond opening Appendix 1 Appendix 2 Appendix 3. Index
Preface 1. Introduction 2. Macromolecular stability 3. Lattice dynamics 4. Effective phonon theory 5. Premelting disrupted chemical bonds 6. Co-operative melting 7. Strained chemical bonds: salt and pressure effects 8. Bond disruption and conformation change: B to Z confirmation change in DNA 9. Hydration effects: structural water 10. Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA bonding constant 11. Non repeating DNA 12. Cutting and splicing: junctions, inserts and the replicating fork 13. Interaction between a helix and a single attached molecule 14. Energy considerations in bond opening Appendix 1 Appendix 2 Appendix 3. Index
Es gelten unsere Allgemeinen Geschäftsbedingungen: www.buecher.de/agb
Impressum
www.buecher.de ist ein Shop der buecher.de GmbH & Co. KG Bürgermeister-Wegele-Str. 12, 86167 Augsburg Amtsgericht Augsburg HRA 13309