Molecular understanding of cancer and cancer progression is at the forefront of many research programs today, and high-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the stucture, organization, and function of cells, tissues and organisms. Complex mathematical, statistical and bioinformatics tools are required to extract, handle and process data and this book, edited by two leading researchers with contributions from carefully chosen experts, makes these tools available to a wide range of researchers, in a single coherent book volume.…mehr
Molecular understanding of cancer and cancer progression is at the forefront of many research programs today, and high-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the stucture, organization, and function of cells, tissues and organisms. Complex mathematical, statistical and bioinformatics tools are required to extract, handle and process data and this book, edited by two leading researchers with contributions from carefully chosen experts, makes these tools available to a wide range of researchers, in a single coherent book volume.
Carsten Wiuf obtained his PhD in mathematical biology from the University of Aarhus in 1998. Afterwards he spent 4 years in Oxford at the Department of Statistics before joining a biotech company in Boston. In 2003 he became Professor of Bioinformatics at the University of Aarhus. He has co-authored the book Gene Genealogies, Variation and Evolution (OUP). Claus L. Andersen earned his PhD in cancer biology from the University of Aarhus in 2002. In 2002 he became an assistant professor at the University of Aarhus and later in 2005 an associated professor. Today he is heading the colorectal cancer research group at the Molecular Diagnostic Laboratory, Aarhus University Hospital. Both have worked on informatics approaches to the analysis of molecular cancer data and have practical as well as theoretical experience with development of bioinformatics and statistical methods for analysis of molecular data.
Inhaltsangabe
* Preface * 1: Emily Webb and Richard Houlston: Association Studies * 2: Cameron Brennan: Methods for DNA Copy Number Derivations * 3: Carsten Wiuf, Philippe Lamy, and Claus L Andersen: Methods for Derivation of LOH and Allelic Copy Numbers Using SNP Arrays * 4: Outi Monni and Sampsa Hautaniemi: Bioinformatics of gene expression and copy number data integration * 5: Fabian Model, Jörn Lewin, Catherine Lofton-Day, and Gunter Weiss: Analysis of DNA Methylation in Cancer * 6: Ming Yi and Robert M Stephens: Pathway Analysis: Pathway Signatures and Classification * 7: Wendy Lockwood Banka, Matthew J Anstett, and Daniel R Rhodes: Two Methods for Comparing Genomic Data Across Independent Studies in Cancer Research: Meta-analysis and Oncomine Concepts Map * 8: Lue Ping Zhao and Jessica Andriesen: Bioinformatic Approaches to the Analysis of Alternative Splicing Variants in Cancer Biology * Index
* Preface * 1: Emily Webb and Richard Houlston: Association Studies * 2: Cameron Brennan: Methods for DNA Copy Number Derivations * 3: Carsten Wiuf, Philippe Lamy, and Claus L Andersen: Methods for Derivation of LOH and Allelic Copy Numbers Using SNP Arrays * 4: Outi Monni and Sampsa Hautaniemi: Bioinformatics of gene expression and copy number data integration * 5: Fabian Model, Jörn Lewin, Catherine Lofton-Day, and Gunter Weiss: Analysis of DNA Methylation in Cancer * 6: Ming Yi and Robert M Stephens: Pathway Analysis: Pathway Signatures and Classification * 7: Wendy Lockwood Banka, Matthew J Anstett, and Daniel R Rhodes: Two Methods for Comparing Genomic Data Across Independent Studies in Cancer Research: Meta-analysis and Oncomine Concepts Map * 8: Lue Ping Zhao and Jessica Andriesen: Bioinformatic Approaches to the Analysis of Alternative Splicing Variants in Cancer Biology * Index
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