Due to the compound structure of the maxillofacial framework, it creates a lot of difficulty for the restoration of the defect. The incredible potential stem cells hold to treat a variety of diseases and to slow down aging makes them an endlessly exciting area of scientific research. There is enormous potential in human stem cells. Most therapies or treatments eventually aim to enhance tissue regeneration and stem cell engineering has opened a new path to regenerative medicine. After several decades of experiments, stem cell therapy is becoming a magnificent game changer for medicine.With each experiment, the capabilities of stem cells are growing, although there are still many obstacles to overcome. Regardless, the influence of stem cells in regenerative medicine and transplantology is immense.