Stereoselective Synthesis of Biologically Active Novel Heterocycles

Stereoselective Synthesis of Biologically Active Novel Heterocycles

in Drug Discovery

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Many of the drugs in human medicine are chiral because they bind to enzymes and receptors to elicit biological activity. Both enzymes and receptors are chiral and therefore in a chiral drug molecule one of the enantiomer is more active than the other. Most of the drugs are also heterocyclic in nature. In the present study we have conceived ideas of what heterocycles might show activity against a particular disease based on their bindings at enzyme or receptor level and investigated the role of chirality in these molecules. Novel synthetic methodologies were developed for the enantioselective s...