Stimulus-Response Curves: Descriptors of Corticospinal Tract Function - Ghinani, Sasan
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Motor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) are used to asses corticospinal tract (CST) function in clinical practice. Advancements in technology have increased TMS precision yet clinical protocols do not reflect the gain in precision required for neuroscientific research. The aim of this study was to determine whether parameters extrapolated from MEP responses accurately reflect CST function. TMS was administered to healthy controls and acute subcortical stroke patients. A sigmoid-shaped dose-response curve was observed in control subjects and patients…mehr

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Produktbeschreibung
Motor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) are used to asses corticospinal tract (CST) function in clinical practice. Advancements in technology have increased TMS precision yet clinical protocols do not reflect the gain in precision required for neuroscientific research. The aim of this study was to determine whether parameters extrapolated from MEP responses accurately reflect CST function. TMS was administered to healthy controls and acute subcortical stroke patients. A sigmoid-shaped dose-response curve was observed in control subjects and patients with lesions outside the CST. Relative amplitude of MEPs is the best descriptor of CST integrity. Absence of a sigmoid relationship indicates CST impairment.
Autorenporträt
Sasan completed his bachelor¿s degree in the faculty of Health Sciences, school of Human Kinetics in 2007 at the University of Ottawa. He then completed his master¿s degree in Neurological Sciences and Neurosurgery at McGill University. Since completing his master¿s in 2009, he has been working as a professor at John Abbott College in Montreal.