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Rare, minority, orphan or rare diseases, including those of genetic origin, are diseases that are life-threatening or chronically disabling. Mycosis Fungoides (Cutaneous Malignant Disease), Toxic Epidermal Necrolysis (severe allergic drug reaction) and Cavernous Sinus Thrombosis (affectation in the Central Nervous System); are rare diseases that seriously affect the health of the individual today, so the main objective of this research is to provide the necessary data to identify these diseases with greater speed, efficiency and certainty, treat them in the shortest possible time and reduce the great mortality they cause.