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Innovation is a powerful force for sustainable economic growth. Innovation is closely linked with economic growth and productivity gains. Strengthening the conceptual and empirical links between innovation and economic performance is a primary objective of the Innovation Strategy. In recent years National Innovation System (NIS) is accepted as a conceptual framework and analytical instrument for countries' innovation activities by the international organizations such as OECD (Organization for Economic Cooperation and Development), UNCTAD and Euro stat. This Research study focuses on the effective formulation and implementation of a national innovation system. It emphasizes that a concept of regional innovation system is a good tool to generate an effective national innovation system, as it can effectively create different regional innovation systems in different regions. Based on this theoretical review, this research will analyze Iranian national innovation systems in terms of mapping of innovation actors.