Strategies for Reducing Drug and Chemical Residues in Food Animals

Herausgeber: Baynes, Ronald E; Riviere, Jim E

• Gebundenes Buch

Produktbeschreibung

This book presents strategies to reduce drug and chemical residues in food from livestock production, and also some of the newer technologies and theories that will shape drug residues management in the future. One of the novel features of this book is that it ties in the realities of veterinary clinical practice and use of these drugs in food animals with regulatory standards and mitigation practices. Highlighting approaches from around the world, the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. The first section focuses on strategies that are part of public policy in national and international agencies and how these agencies assess the toxicology of veterinary drugs and contaminants. These chapters provide a general introduction to basic pharmacokinetic principles pertaining to estimating a safe withdrawal time for veterinary drugs and contaminants. The second half focuses on the use of major drug classes in livestock food animal production systems and those drugs most likely targeted for regulatory policy, pharmacokinetic modelling, and chemical residue monitoring.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 344
• Erscheinungstermin: 15. September 2014
• Englisch
• Abmessung: 240mm x 161mm x 23mm
• Gewicht: 671g
• ISBN-13: 9780470247525
• ISBN-10: 0470247525
• Artikelnr.: 40626135

Autorenporträt

Ronald Baynes is a Professor of Pharmacology and Director of the Center of Chemical Toxicology Research and Pharmacokinetics at the College of Veterinary Medicine at North Carolina State University and Fellow, American Academy of Veterinary Pharmacology and Therapeutics He has consulted for the National Institute of Environmental Health Sciences, the US Environmental and Protection Agency, and National Institute of Occupational Safety and Health on chemical exposure-related topics. Jim Riviere is The MacDonald Chair in Veterinary Medicine and University Distinguished Professor at Kansas State University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a fellow of the Academy of Toxicological Sciences.

Inhaltsangabe

Preface vii
Contributors ix
1 Importance of Veterinary Drug Residues 1
Ronald E. Baynes and Jim E. Riviere
2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis
for Determination ofWithdrawal Periods for Animal Drugs 9
Sanja Modric
3 Evaluation of Drug Residue Depletion in the Edible Products of
Food-Producing Animals forEstablishing Withdrawal Periods and Milk Discard
Times 35
Dong Yan
4 Establishing Maximum Residue Limits in Europe 49
Kornelia Grein and Isaura Duarte
5 Methods to Derive Withdrawal Periods in the European Union 65
G. Johan Schefferlie and Stefan Scheid
6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 81
Sharon E. Mason
7 Physiologically Based Pharmacokinetic Modeling 95
Jennifer Buur
8 Residue Avoidance in Beef Cattle Production Systems 115
Virginia Fajt and Dee Griffin
9 Residue Avoidance in Dairy Cattle Production Systems 137
Geof Smith
10 Residue Avoidance in Aquaculture Production Systems 161
Renate Reimschuessel
11 Residue Avoidance in Small Ruminant Production Systems 193
Kevin Anderson and Reha Azizoglu
12 Residue Avoidance in Swine Production Systems 221
Ronald E. Baynes and Glen Almond
13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in
Livestock Commodities233
Hui li
14 The Food Animal Residue Avoidance Databank: An Example of Risk
Management of VeterinaryDrug Residues 289
Thomas W. Vickroy, Ronald E. Baynes, Lisa Tell and Jim E. Riviere
15 Risk Management of Chemical Contaminants in Livestock 303
Ronald E. Baynes and Jim E. Riviere
Index 313