By the end of 1990s, fish and fisheries products were the most affordable animal protein sources by most resource poor communities in the Sub-African. However, following the collapse of major fishery grounds, fish protein is currently more expensive than any other animal protein source. This leads to marginalization of most rural communities and inability to afford proteins. Moreover, to bridge this supply and demand gap however, aquaculture turns out to be the most promising venture for African farmers. However, following the need to increase production in fish farming endevours, farmers are tempted to stock more into their fish farming facilities. Overstocking coupled with poor water conditions (temperature, pH, dissolved oxygen, excessive nutrients etc,) are major predisposing factors for fish immunity suppression and disease eruption. This books enlightens the occurrence of Streptococcosis, which is among the most common disease in tropical fish farming.