Job and family are the two domains causing stress among employees. The severe harmful implications of stress on physical and mental health of bank managers can not be ignored. The findings of the study can provide guidelines to the industry in general and banking in particular in framing human resource policies and strategies that can address the causes of stress. This study has potential to contribute to economies like India where lot of structural changes are taking place, nature of competition is ever evolving, work culture is becoming performance oriented,human resource policies are making employers more powerful, and contract jobs and less job security are beginning to define employment relationship and where it seems that the worst of stress is yet to come.The study has joined in the efforts to introduce non work factors along with work factors and individual differences as exogeneous factors to examine the stress and health relationship. In addition, the efforts are directed to respond positively to the often proclaimed call to approach stress research from a multidisciplinary perspective.