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Cancer is a demon which threatens the life of many both by its presence and likelihood of arrival in the present day world marked by stressful living. The main objectives of the proposed research were, to explore the level of stress, coping strategies, and quality of life of patients with cancer and to find out the relationship between the stress, coping strategies, quality of life, ECOGPS and the age of the patients with cancer pre- and post-medical intervention (Part A); to develop psychological intervention package based on Part A results; and to test the effectiveness of the developed package on a new sample of patients with cancer by measuring the same variables as in Part A, pre- and post-medical and psychological intervention (Part C). The study is a quasi-experimental design conducted in three parts. During the Part A, 105 patients and in Part C 30 patients with cancer between the ages of 28 - 65 years were included in the study with equal distribution of subjects from three types of cancer viz. lung, breast and head-neck-cancer in both Part A and Part C. The tools used were Questionnaire on Stress in Cancer Patients- Revised Version (QSC-R23) to measure stress level, Brief COPE for coping, European Organization for the Treatment and Research of Cancer Quality of Life Questionnaire-QLQ-C30, version 3.0 to assess the quality of life, during pre- and post- Medical Intervention Assessment (pre- and post-MIA) in Part A. A psychological intervention package was developed during Part B with psychoeducation, relaxation, and Cognitive Behaviour Therapy modules which were applied along with medical intervention in Part C. The impact of psychoeducation was measured using Cancer Information Scale, impact of relaxation by using Visual Analogue Scale and impact of cognitive behaviour therapy was measured by using.