In these modern days the Buildings are made to fulfill our basic aspects and better Serviceability. It is not an issue to construct a Building any how its, important to construct an efficient building which will serve for many years without showing any failure. A structure can be defined as a body which can resist the applied loads without appreciable deformations. Structure analysis involves the determination of the forces and displacements of the structures or components of a structure. Design process involves the selection and detailing of the components that make up the structural system. In this book, brief study and analysis of mutli-storey building of 100-stories is done in consideration with dead load. For the analysis two approaches have been followed out: sequential and simultaneous with the help of software Stadd Pro. The analysis part is then trained via ANN software.