Philip E. Bourne, Helge Weissig
Structural Bioinformatics
Herausgegeben von Bourne, Philip E.; Weissig, Helge
Philip E. Bourne, Helge Weissig
Structural Bioinformatics
Herausgegeben von Bourne, Philip E.; Weissig, Helge
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The genomics and post-genomics revolutions in biology have led to a widespread appreciation of the importance of three-dimensional structural data for understanding function. This text aims to provide a basic understanding of the theories, associated algorithms, resources and tools used in structural bioinformatics. The reader should emerge with the ability to make effective use of protein, DNA, RNA, carbohydrate and complex structures to better understand biological function. Moreover, the book draws a clear connection between structural studies and the rational design of new therapies.
The genomics and post-genomics revolutions in biology have led to a widespread appreciation of the importance of three-dimensional structural data for understanding function. This text aims to provide a basic understanding of the theories, associated algorithms, resources and tools used in structural bioinformatics. The reader should emerge with the ability to make effective use of protein, DNA, RNA, carbohydrate and complex structures to better understand biological function. Moreover, the book draws a clear connection between structural studies and the rational design of new therapies.
Produktdetails
- Produktdetails
- Verlag: WILEY & SONS; WILEY-LISS
- Seitenzahl: 649
- Englisch
- Abmessung: 255mm
- Gewicht: 1224g
- ISBN-13: 9780471201991
- ISBN-10: 0471201995
- Artikelnr.: 11441295
- Herstellerkennzeichnung Die Herstellerinformationen sind derzeit nicht verfügbar.
- Verlag: WILEY & SONS; WILEY-LISS
- Seitenzahl: 649
- Englisch
- Abmessung: 255mm
- Gewicht: 1224g
- ISBN-13: 9780471201991
- ISBN-10: 0471201995
- Artikelnr.: 11441295
- Herstellerkennzeichnung Die Herstellerinformationen sind derzeit nicht verfügbar.
Philip E. Bourne is a Professor in the Department of Pharmacology at the University of California San Diego and Director of Integrated Biosciences at the San Diego Supercomputer Center. He is also currently the President of the International Society for Computational Biology (ISCB). Dr. Bourne is the author of over 100 peer reviewed scientific papers and three previous books.
Helge Weissig is a Project Leader in Bioinformatics at ActivX Biosciences, a proteomics company, and also co-coordinates the Bioinformatics Certificate program for UCSD Extension. After doing his post-doctoral work with Prof. Bourne at the San Diego Supercomputer Center, he became the Technical Project Manager for the RCSB Protein Data Bank (PDB) at UCSD.
Helge Weissig is a Project Leader in Bioinformatics at ActivX Biosciences, a proteomics company, and also co-coordinates the Bioinformatics Certificate program for UCSD Extension. After doing his post-doctoral work with Prof. Bourne at the San Diego Supercomputer Center, he became the Technical Project Manager for the RCSB Protein Data Bank (PDB) at UCSD.
From the contents:
Section I. Introduction
Defining Bioinformatics and Structural Bioinformatics (R. Altman & J. Dugan)
Fundamentals of Protein Structure (E. Scheeff & L. Fink)
Fundamentals of DNA and RNA Structure (S. Neidle, et al.)
Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination (P. Adams, et al.)
Macromolecular Structure Determination by NMR Spectroscopy (J. Markley, et al.)
Electron Microscopy (N. Volkmann & D. Hanein)
Molecular Visualization (J. Tate)
Section II. Data Representation and Databases
The PDB Format, mmCIF Formats, and Other Data Formats (J. Westbrook & P. Fitzgerald)
The Protein Data Bank (The PDB Team)
The Nucleic Acid Database (H. Berman, et al.)
Other Structure-Based Databases (H. Weissig & P. Bourne)
Section III. Comparative Features
Protein Structure Evolution and the SCOP Database (B. Reddy & P. Bourne)
The CATH Domain Structure Database (C. Orengo, et al.)
Structural Quality Assurance (R. Laskowski)
All-Atom Contacts: A New Approach to Structure Validation (J. Richardson)
Structure Comparison and Alignment (P. Bourne & I. Shinadyalov)
Section IV. Structure and Functional Assignment
Secondary Structure Assignment (C. Andersen & B. Rost)
Identifying Structural Domains in Proteins (L. Wernisch & S. Wodak)
Inferring Protein Function from Structure (G. Bartlett, et al.)
Section V. Protein Interactions
Prediction of Protein-Protein Interactions from Evolutionary Information (A. Valencia & F. Pazos)
Electrostatic Interactions (N. Baker & J. McCammon)
Section VI. Proteins as Drud Targets
Principles and Methods of Docking and Ligand Design (J. Krumrine, et al.)
Structural Bioinformatics in Drug Discovery (E. Fauman, et al.)
Section VII. Structure Prediction
CASP and CAFASP Experiments and Their Findings (P. Bourne)
Homology Modeling (E. Krieger, et al.)
Fold Recognition Methods (A. Godzik)
Ab Initio Methods (D. Chivian, et al.)
Prediction in 1D: Secondary Structure, Membrane Helices, and Accessibility (B. Rost)
Section VIII. The Future
Structural Genomics (S. Burley & J. Bonanno)
Index
Section I. Introduction
Defining Bioinformatics and Structural Bioinformatics (R. Altman & J. Dugan)
Fundamentals of Protein Structure (E. Scheeff & L. Fink)
Fundamentals of DNA and RNA Structure (S. Neidle, et al.)
Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination (P. Adams, et al.)
Macromolecular Structure Determination by NMR Spectroscopy (J. Markley, et al.)
Electron Microscopy (N. Volkmann & D. Hanein)
Molecular Visualization (J. Tate)
Section II. Data Representation and Databases
The PDB Format, mmCIF Formats, and Other Data Formats (J. Westbrook & P. Fitzgerald)
The Protein Data Bank (The PDB Team)
The Nucleic Acid Database (H. Berman, et al.)
Other Structure-Based Databases (H. Weissig & P. Bourne)
Section III. Comparative Features
Protein Structure Evolution and the SCOP Database (B. Reddy & P. Bourne)
The CATH Domain Structure Database (C. Orengo, et al.)
Structural Quality Assurance (R. Laskowski)
All-Atom Contacts: A New Approach to Structure Validation (J. Richardson)
Structure Comparison and Alignment (P. Bourne & I. Shinadyalov)
Section IV. Structure and Functional Assignment
Secondary Structure Assignment (C. Andersen & B. Rost)
Identifying Structural Domains in Proteins (L. Wernisch & S. Wodak)
Inferring Protein Function from Structure (G. Bartlett, et al.)
Section V. Protein Interactions
Prediction of Protein-Protein Interactions from Evolutionary Information (A. Valencia & F. Pazos)
Electrostatic Interactions (N. Baker & J. McCammon)
Section VI. Proteins as Drud Targets
Principles and Methods of Docking and Ligand Design (J. Krumrine, et al.)
Structural Bioinformatics in Drug Discovery (E. Fauman, et al.)
Section VII. Structure Prediction
CASP and CAFASP Experiments and Their Findings (P. Bourne)
Homology Modeling (E. Krieger, et al.)
Fold Recognition Methods (A. Godzik)
Ab Initio Methods (D. Chivian, et al.)
Prediction in 1D: Secondary Structure, Membrane Helices, and Accessibility (B. Rost)
Section VIII. The Future
Structural Genomics (S. Burley & J. Bonanno)
Index
From the contents:
Section I. Introduction
Defining Bioinformatics and Structural Bioinformatics (R. Altman & J. Dugan)
Fundamentals of Protein Structure (E. Scheeff & L. Fink)
Fundamentals of DNA and RNA Structure (S. Neidle, et al.)
Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination (P. Adams, et al.)
Macromolecular Structure Determination by NMR Spectroscopy (J. Markley, et al.)
Electron Microscopy (N. Volkmann & D. Hanein)
Molecular Visualization (J. Tate)
Section II. Data Representation and Databases
The PDB Format, mmCIF Formats, and Other Data Formats (J. Westbrook & P. Fitzgerald)
The Protein Data Bank (The PDB Team)
The Nucleic Acid Database (H. Berman, et al.)
Other Structure-Based Databases (H. Weissig & P. Bourne)
Section III. Comparative Features
Protein Structure Evolution and the SCOP Database (B. Reddy & P. Bourne)
The CATH Domain Structure Database (C. Orengo, et al.)
Structural Quality Assurance (R. Laskowski)
All-Atom Contacts: A New Approach to Structure Validation (J. Richardson)
Structure Comparison and Alignment (P. Bourne & I. Shinadyalov)
Section IV. Structure and Functional Assignment
Secondary Structure Assignment (C. Andersen & B. Rost)
Identifying Structural Domains in Proteins (L. Wernisch & S. Wodak)
Inferring Protein Function from Structure (G. Bartlett, et al.)
Section V. Protein Interactions
Prediction of Protein-Protein Interactions from Evolutionary Information (A. Valencia & F. Pazos)
Electrostatic Interactions (N. Baker & J. McCammon)
Section VI. Proteins as Drud Targets
Principles and Methods of Docking and Ligand Design (J. Krumrine, et al.)
Structural Bioinformatics in Drug Discovery (E. Fauman, et al.)
Section VII. Structure Prediction
CASP and CAFASP Experiments and Their Findings (P. Bourne)
Homology Modeling (E. Krieger, et al.)
Fold Recognition Methods (A. Godzik)
Ab Initio Methods (D. Chivian, et al.)
Prediction in 1D: Secondary Structure, Membrane Helices, and Accessibility (B. Rost)
Section VIII. The Future
Structural Genomics (S. Burley & J. Bonanno)
Index
Section I. Introduction
Defining Bioinformatics and Structural Bioinformatics (R. Altman & J. Dugan)
Fundamentals of Protein Structure (E. Scheeff & L. Fink)
Fundamentals of DNA and RNA Structure (S. Neidle, et al.)
Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination (P. Adams, et al.)
Macromolecular Structure Determination by NMR Spectroscopy (J. Markley, et al.)
Electron Microscopy (N. Volkmann & D. Hanein)
Molecular Visualization (J. Tate)
Section II. Data Representation and Databases
The PDB Format, mmCIF Formats, and Other Data Formats (J. Westbrook & P. Fitzgerald)
The Protein Data Bank (The PDB Team)
The Nucleic Acid Database (H. Berman, et al.)
Other Structure-Based Databases (H. Weissig & P. Bourne)
Section III. Comparative Features
Protein Structure Evolution and the SCOP Database (B. Reddy & P. Bourne)
The CATH Domain Structure Database (C. Orengo, et al.)
Structural Quality Assurance (R. Laskowski)
All-Atom Contacts: A New Approach to Structure Validation (J. Richardson)
Structure Comparison and Alignment (P. Bourne & I. Shinadyalov)
Section IV. Structure and Functional Assignment
Secondary Structure Assignment (C. Andersen & B. Rost)
Identifying Structural Domains in Proteins (L. Wernisch & S. Wodak)
Inferring Protein Function from Structure (G. Bartlett, et al.)
Section V. Protein Interactions
Prediction of Protein-Protein Interactions from Evolutionary Information (A. Valencia & F. Pazos)
Electrostatic Interactions (N. Baker & J. McCammon)
Section VI. Proteins as Drud Targets
Principles and Methods of Docking and Ligand Design (J. Krumrine, et al.)
Structural Bioinformatics in Drug Discovery (E. Fauman, et al.)
Section VII. Structure Prediction
CASP and CAFASP Experiments and Their Findings (P. Bourne)
Homology Modeling (E. Krieger, et al.)
Fold Recognition Methods (A. Godzik)
Ab Initio Methods (D. Chivian, et al.)
Prediction in 1D: Secondary Structure, Membrane Helices, and Accessibility (B. Rost)
Section VIII. The Future
Structural Genomics (S. Burley & J. Bonanno)
Index