Structural Bioinformatics

Methods and Protocols
Herausgegeben:Gáspári, Zoltán

• Broschiertes Buch

Produktbeschreibung

This volume looks at the latest techniques used to perform comparative structure analyses, and predict and evaluate protein-ligand interactions. The chapters in this book cover tools and servers such as LiteMol; Bio3D-Web; DALI; CATH; HoTMuSiC, a contact-base protein structure analysis tool known as CAD-Score; PyDockSaxs and HADDOCK; CombDock and DockStar; the BioMagResBank database; as well as BME and CoNSEnsX+. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive, Structural Bioinformatics: Methods and Protocols is a practical guide for researchers to learn more about the aforementioned tools to further enhance their studies in the growing field of structural bioinformatics.
Chapter 13 isavailable open access under a CC-BY 4.0 license via link.springer.com.

Produktdetails

• Methods in Molecular Biology 2112
• Verlag: Humana / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-0716-0272-0
• 1st ed. 2020
• Seitenzahl: 268
• Erscheinungstermin: 1. Februar 2021
• Englisch
• Abmessung: 254mm x 178mm x 15mm
• Gewicht: 511g
• ISBN-13: 9781071602720
• ISBN-10: 1071602721
• Artikelnr.: 60874788

Inhaltsangabe

Visualization and Analysis of Protein Structures with LiteMol Suite.- Comparative Protein Structure Analysis with Bio3D-Web.- Using DALI for Protein Structure Comparison.- Assessing Protein Function through Structural Similarities with CATH.- Protein Thermal Stability Engineering using HoTMuSiC.- Contact Area-Based Structural Analysis of Proteins and their Complexes using CAD-Score.- A Comprehensive Computational Platform to Guide Drug Development using Graph-Based Signature Methods.- Systematic Exploration of Binding Modes of Ligands on Drug Targets.- Using MemBlob to Analyze Transmembrane Regions Based on Cryo-EM Maps.- Structural Characterization of Protein-Protein Interactions with pyDockSAXS.- Protein-Protein Modeling using Cryo-EM Restraints.- Modeling of Multimolecular Complexes.- Biological Assembly Comparison with VAST+.- BioMagResBank (BMRB) as a Resource for Structural Biology.- Integrating MolecularSimulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach.- Evaluation and Selection of Dynamic Protein Structural Ensembles with CoNSEnsX+.