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This monograph deals with obtaining new effective drugs and obtaining new biologically active compounds on the basis of plant origin of polyphenol - gossypol, which requires a systematic study of new polymorphs and clathrates of gossypol, determination of their structure and study of thermal behavior.This monograph serves the fulfillment of tasks provided in the Strategy of Action and Development of Uzbekistan and a number of Resolutions of the President of the Republic of Uzbekistan, as well as corresponds to the priority directions of development of science and technology both in the country and in the world.